Sökning: "cellular localisation"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden cellular localisation.

  1. 1. Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor

    Författare :Hanna Wallin; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cathepsin; cell line; co-localisation; cystatin C; internalisation; legumain;

    Sammanfattning : Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. LÄS MER

  3. 2. Structural and functional analyses of infectious pancreatic necrosis virus (IPNV)

    Författare :Anna Hjalmarsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cellular localisation; glycosylation; VP3-RNA cores; virus-specified components; immuno dot blot; TCID50; IPNV; purification; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Infectious pancreatic necrosis virus (IPNV) is a naked virus of an uncomplicated structure. In the interior part of the virion, the two segments of double-stranded RNA are located together with the minor structural protein VP1. This protein is detected in its free form as well as linked to the genome. LÄS MER

  4. 3. CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 8 (CEACAM8) : Purification, Characterization, Cellular and Clinical Studies

    Författare :Linshu Zhao; Per Venge; Claes Dahlgren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; human neutrophil; human eosinophil; granule proteins; CEA; CEACAM8; G-CSF; ELISA; subcellular fractionation; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : A 95-kDa protein was purified from normal human granulocytes. The protein reacted with a monoclonal antibody against CEACAM8. MALDI-Tof and MS/MS analyses revealed the protein to be a CGM6 gene product. Thus, the protein was proved to be identical to CEACAM8. LÄS MER

  5. 4. Amyloid precursor protein : cellular studies and animal models

    Författare :Tatjana Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived from proteolysis of the amyloid precursor protein (APP) by consecutive action of β and γ-secretases. LÄS MER

  7. 5. Cellular models of human brain disorders from skin to brain

    Författare :Mansoureh Shahsavani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Studying human brain development and disorders is very challenging. In the absence of comparable model organisms, human-related models, and limitations to obtain live cells from the human brain, induced Pluripotent Stem Cell (iPSC) technology, in particular, provided a unique tool to study the disease mechanisms and investigate potential treatments. LÄS MER