Sökning: "cell-to-cell variability"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden cell-to-cell variability.

  1. 1. Kinetic Models in Life Science — Contributions to Methods and Applications

    Författare :Joachim Almquist; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NLME modeling; kinetic models; FOCE; Mig1; cell-to-cell variability; pharmacokinetics; parameter estimation; ticagrelor; atrial fibrillation; Kv1.5;

    Sammanfattning : Kinetic models in life science combine mathematics and biology to answer questions from areas such as cell biology, physiology, biotechnology, and drug development. The idea of kinetic models is to represent a biological system by a number of biochemical reactions together with mathematical expressions for the reaction kinetics, i.e. LÄS MER

  3. 2. Potato mop-top virus: Variability, Movement and Suppression of Host Defence

    Författare :Pruthvi Balachandra Kalyandurg; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Potato mop-top virus (PMTV) causes an economically damaging disease called potato spraing. Despite being reported across the potato growing regions in the world, very little genetic variability has been reported for the virus. LÄS MER

  4. 3. Systems-level investigation of the interaction between glucose metabolism and the Snf1/Mig1 signalling pathway

    Författare :Niek Welkenhuysen; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glucose signalling; microfluidics; Saccharomyces cerevisiae;

    Sammanfattning : Saccharomyces cerevisiae Snf1 and its mammalian homolog, AMPK, are members of a protein kinase family present throughout the Eukaryotic kingdom. AMPK plays an essential role in different cellular processes and is involved in diseases such as diabetes, obesity and cancer. LÄS MER

  5. 4. Dynamic single-cell modelling of nutrient signalling in budding yeast

    Författare :Sebastian Persson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nutrient signalling; single-cell; mixed-effects models; stochastic dynamic models; Bayesian inference;

    Sammanfattning : To survive in environments with constantly changing nutrient levels the bud- ding yeast Saccharomyces cerevisiae has a sophisticated nutrient sensing system. A central component of this system is the SNF1 signalling pathway, which primarily helps yeast adapt to glucose limited conditions. LÄS MER

  7. 5. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

    Författare :Loubna Bendrioua; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

    Sammanfattning : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. LÄS MER