Sökning: "cell-penetrating peptide"
Visar resultat 26 - 30 av 67 avhandlingar innehållade orden cell-penetrating peptide.
26. Rational design of novel cell-penetrating peptides
Sammanfattning : Although cell-penetrating peptides (CPPs) have been an active field of research for over 20 years there are still properties such as efficiency and stability that must be improved for CPPs to reach their full potential as delivery vectors.In this thesis two peptides were designed for non-covalent oligonucleotide delivery, in an attempt to overcome two major issues hampering wider use of CPPs, namely low stability and endosomal entrapment. LÄS MER
27. Cell-penetrating peptides in model membrane systems : Interaction, structure induction and membrane effects
Sammanfattning : Despite continuing advances in the development of macromolecules, including peptides, proteins, and oligonucleotides, for therapeutic purposes, the successful application of these hydrophilic molecules has so far been hampered by their inability to efficiently traverse the plasma membrane. The discovery of a class of peptides (cell-penetrating peptides, CPPs) with the ability to mediate the non-invasive and efficient import of a whole host of cargoes, both in vitro and in vivo, has provided a new means by which the problem associated with cellular delivery can be circumvented. LÄS MER
28. Gene therapy tools: oligonucleotides and peptides
Sammanfattning : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. LÄS MER
29. Cell-penetrating peptides targeting glioblastomas for nucleic acid delivery in the blood-brain barrier model
Sammanfattning : Glioblastoma multiforme is the most aggressive form of malignant brain tumor with poor prognosis. The efficacy of brain cancer treatment by chemotherapeutics is limited by the blood-brain barrier (BBB) which allows less than 2% of the small molecules and blocks almost all the macromolecules to transport into the brain. LÄS MER
30. Rational design and applications of cell-penetrating peptides
Sammanfattning : Cell-penetrating peptides are peptides capable of translocating the cellular membrane and entering the cell, either alone or together with a cargo. Potential applications of cell-penetrating peptides include drug delivery and gene therapy. LÄS MER
