Sökning: "cell-cell communication"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden cell-cell communication.

  1. 1. Role of Cell-cell Interactions and Palmitate on β-cells Function

    Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER

  3. 2. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

    Författare :Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

    Sammanfattning : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. LÄS MER

  4. 3. Macrophage-material surface interactions

    Författare :Christina Gretzer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; biomaterials; cell-cell interactions; cell-material interactions; cytokines; differentiation; fibrinogen; hydrogen peroxide; LPS; monocytes; particles;

    Sammanfattning : Material surface-stimulated activation of the macrophage and the release of mediators has been suggested to be an important factor for inflammation and tissue regeneration around biomedical implants. Macrophage interactions with particles released from implants as well as macophage-bacteria interactions are also involved in implant loosening processes. LÄS MER

  5. 4. Metabolic communication between individual yeast cells

    Författare :Martin Mojica Benavides; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolic synchronization; Single-cell; glycolytic oscillations; synchronization waves;

    Sammanfattning : With the recent progress in sensitive cell manipulation and microfabrication techniques, glycolytic oscillations in yeast have been observed at a single-cell level. It was shown that individually, oscillating cells could entrain their phases by periodic external perturbations. LÄS MER

  7. 5. Exploring the tissue-specific nature of the Wnt cell signaling system : The complex world of cell communication and the search for the Achilles heel of cancer

    Författare :Simon Söderholm; Claudio Cantù; Mikael Benson; Stefan Hoppler; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling; β-catenin; Development; Cancer; Stem cells; Omics; Bioinformatics;

    Sammanfattning : The Wnt signaling pathway is a biological mechanism for cell-cell communication found across all species of the animal kingdom. This pathway plays a major role in virtually all stages of embryonic development, and it governs central aspects of stem cell biology, regeneration, and tissue homeostasis. LÄS MER