Sökning: "cell surface proteoglycan"
Visar resultat 1 - 5 av 31 avhandlingar innehållade orden cell surface proteoglycan.
1. Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development
Sammanfattning : Heparan sulfate (HS) is a sulfated glycosaminoglycan expressed by all cells in the body. It is found at the cell surface and in the extracellular matrix where it binds a large amount of various ligands including growth factors and morphogens. LÄS MER
2. Biglycan as a modulator of fibrous connective tissue
Sammanfattning : Fibrous connective tissue contains fibroblasts distributed in a complex network of extracellular matrix molecules, such as proteoglycans. The small proteoglycans biglycan and decorin are composed of a protein core substituted with two and one glycosaminoglycan (GAG) chain, respectively. LÄS MER
3. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
Sammanfattning : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. LÄS MER
4. Biosynthesis of decorin and glypican glycosaminoglycan chains
Sammanfattning : Proteoglycans consist of core proteins substituted with glycosaminoglycan chains. The galactosaminoglycans (GlcUA/IdoUA-GalNAc) and the glucosaminoglycans (GlcUA/IdoUA-GlcNAc) are both initiated on the same tetrasaccharide linkage region GlcUA-Gal-Gal-Xyl-protein. LÄS MER
5. Biosynthesis of Dermatan Sulphate. Enzymatic mechanism and role of cytokines
Sammanfattning : Dermatan sulphate is a prominent feature of several different proteoglycans and occurs in almost every tissue of the body. It is an unbranched polymer containing the repeating disaccharide unit of N-acetylgalactosamine and D-glucuronic acid or L-iduronic acid. LÄS MER