Sökning: "cell regulatory properties"

Visar resultat 1 - 5 av 139 avhandlingar innehållade orden cell regulatory properties.

  1. 1. Cell cycle regulation in cancer: A noncoding perspective

    Författare :Mohamad Ali; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long Noncoding RNA; lncRNA; Cell cycle; S phase; Mitosis; Checkpoint; Cancer; SCAT7; LY6K-AS;

    Sammanfattning : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. LÄS MER

  3. 2. Exploring the tissue-specific nature of the Wnt cell signaling system : The complex world of cell communication and the search for the Achilles heel of cancer

    Författare :Simon Söderholm; Claudio Cantù; Mikael Benson; Stefan Hoppler; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling; β-catenin; Development; Cancer; Stem cells; Omics; Bioinformatics;

    Sammanfattning : The Wnt signaling pathway is a biological mechanism for cell-cell communication found across all species of the animal kingdom. This pathway plays a major role in virtually all stages of embryonic development, and it governs central aspects of stem cell biology, regeneration, and tissue homeostasis. LÄS MER

  4. 3. Molecular mechanism of cell regulatory properties of vitamin D analogues in human cancer cell lines

    Författare :Carina Danielsson; Uppsala universitet; []
    Nyckelord :Medical sciences; vitamin D analogues; retinoids; cancer cell lines; promoter selectivity; cellregulatory properties; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Sammanfattning : The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is a potent modulator of the induction of differentiation and inhibition of cell growth in both malignant and normal cells. Vitamin D and its analogues exert their effects through a transcription factor, the nuclear vitamin D receptor (VDR). LÄS MER

  5. 4. Preparatory Studies to Introduce Regulatory T Cells in Clinical Transplantation

    Författare :David Berglund; Gunnar Tufveson; Olle Korsgren; David Sachs; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transplantation; Tolerance; Cell therapy; Regulatory T cell; In vivo imaging; Cell purification;

    Sammanfattning : Solid organ transplantation has evolved from being an experimental procedure to a life-saving treatment for patients with end-stage organ failure. The risk of losing a transplant due to acute rejection is very low with the use of modern immunosuppressive protocols and the short-term results are impressive. LÄS MER

  7. 5. Bone Development and the Nervous System

    Författare :Gregor Sisask; Olof Nilsson; Anders Bjurholm; Kenneth B Jonsson; André Stark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi;

    Sammanfattning : Innervation of bone influence bone modeling, growth and remodeling. Pro-inflammatory cytokines released after tissue trauma are recognized as neurotrophic factors as well as factors influencing bone formation. The Wnt signaling pathway, essential for cell migration during embryogenesis is found to influence bone formation during fracture healing. LÄS MER