Sökning: "cell protrusions"
Visar resultat 1 - 5 av 24 avhandlingar innehållade orden cell protrusions.
1. Cholesterol in T cells : homeostasis, plasma membrane organization and signaling
Sammanfattning : The plasma membrane of eukaryotic cells contains cholesterol and glycosphingolipids enriched nanodomains known as lipid rafts; which are believed to exist in a liquid ordered (lo) state. Methyl-beta-cyclodextrin (MBCD) is used to deplete cellular cholesterol and a widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts. LÄS MER
2. Regulation of GRAF1 membrane sculpting function during cell movement
Sammanfattning : All eukaryotic cells rely on endocytic events to satisfy a constant need for nutrient and fluid uptake from their surroundings. Endocytosis-dependent turnover of cell surface constituents also serves to control signal transduction and establish morphological changes in response to extracellular stimuli. LÄS MER
3. Micro-scale Platforms for Investigations of Biological Structures
Sammanfattning : This thesis describes the development of innovative micro-scale platforms as a means to address the current challenges within the field of cell biology, and to provide an interface between miniaturized analytical technology and experimental systems for the life sciences. The work includes an analytical platform for rapid assessment of the viability of adherent single cells; a surface patterning strategy for investigations of cell-to-cell communication via protrusions; a versatile microfluidic probe in SU-8 hard-polymer, and a microfabricated millimeter-wave measurement system for the identification and characterization of niosome (non-ionic surfactant vesicle) constituents, which is operated in a label-free, non-invasive manner. LÄS MER
4. Water Fluxes and Cell Migration : How Aquaporin 9 Controls Cell Shape and Motility
Sammanfattning : Prerequisites for all modes of cell migration are cell-substratum interactions that require a sophisticated interplay of membrane dynamics and cytoskeletal rearrangement. Generally, a migrating cell is polarized with a distinct rear and front, from which it extends a wide and thin membrane protrusion- lamellipodium, small fingerlike projections- filopodia, and membrane blisters- blebs. LÄS MER
5. Tissue repair in lung disorders
Sammanfattning : The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. LÄS MER