Sökning: "cell population"

Visar resultat 1 - 5 av 1229 avhandlingar innehållade orden cell population.

  1. 1. Effects of adenosine and acetylcholine on the lacrimal gland

    Författare :Stina K. Carlsson; J. Peter Gierow; Sven Tågerud; Darlene Dartt; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lacrimal gland; adenosine; adenosine receptors; signal transduction; exocrine secretion; tear film; dry eye; Sjögren’s syndrome; acetylcholine; mitogen activated protein kinase; p38; Cell biology; Cellbiologi; Ophtalmology; Oftalmologi; Cell and molecular biology; Cell- och molekylärbiologi; Cell biology; Cellbiologi; Molecular biology; Molekylärbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. LÄS MER

  3. 2. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

    Författare :Azra Alajbegovic; Molekylär kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

    Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER

  4. 3. TGF-beta signaling in cancer

    Författare :Erik Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TGF-β; proliferation; cancer; tumor suppressor; diffuse-type gastric carcinoma; neuroblastoma; nuclear receptor TLX; cancer stem cell; angiogenesis; ABCG2; VHL; HIF2α; hypoxia; Smad3;

    Sammanfattning : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. LÄS MER

  5. 4. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities

    Författare :Wojciech Senkowski; Mårten Fryknäs; Rolf Larsson; Peter Nygren; Mats Gustafsson; Krister Wennerberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; spheroids; high-throughput screening; nitazoxanide; OXPHOS; gene expression profiling; statins; drug repositioning; 3D cell culture; quiescent cells; Medical Science; Medicinsk vetenskap;

    Sammanfattning : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. LÄS MER

  7. 5. Generating Dendritic Cells by Direct Cell Reprogramming. Merging cellular reprogramming with immunology towards the development of novel cancer immunotherapies

    Författare :Fábio Fiúza Rosa; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic Cell; Direct Cell Reprogramming; Single-cell analysis; Immunotherapy;

    Sammanfattning : Cell fate reprogramming towards pluripotency or alternative somatic cell-types has highlighted the plasticity of adult somatic cells, providing new technologies to generate desired cell types for tissue repair or for disease modeling. There is momentum to bring these concepts to immunology by specifying unique immune cellular identities that set in motion immune responses. LÄS MER