Sökning: "cell polarity"
Visar resultat 11 - 15 av 73 avhandlingar innehållade orden cell polarity.
11. Regulation of cell differentiation and invasion by members of the TGFß family
Sammanfattning : Transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) signaling pathways are important in embryonic development and tissue homeostasis, but also have complex roles in the context of cancer. TGFβ promotes epithelial to mesenchymal transition (EMT) a physiological developmental process, often hijacked in different types of cancer, eventually leading to cancer cell invasion and metastasis. LÄS MER
12. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination
Sammanfattning : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. LÄS MER
13. Cdc42 and Rac1 in Pancreatic Tubulogenesis and Islet Formation
Sammanfattning : Tubes form the basic structure of several organs like lungs, kidneys, glandular organs like the pancreas, mammary and salivary glands. Tube formation involves a series of dynamic and interdependent cellular processes, including cytoskeletal reorganization, assembly of intercellular junctional complexes, and cell polarization. LÄS MER
14. Three dimensional mathematical modelling of pronuclei migration for the mouse
Sammanfattning : The main question addressed in this thesis is what happens between the moment when the sperm enters the egg and the fusion of the male and the female pronuclei. Orientation of the apposing pronuclei most likely plays a decisive role in the polarity of the developing embryo. LÄS MER
15. Directing Angiogenesis : Cellular Responses to Gradients in vitro
Sammanfattning : Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. LÄS MER