Sökning: "cell monolayer s"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden cell monolayer s.

1. 1. Study of the Proliferation, Function and Death of Insulin-Producing Beta-Cells in vitro: Role of the Transcription Factor ZBED6

   Författare :Xuan Wang; Nils Welsh; Nils Billestrup; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; Pancreatic beta-cell; Proliferation; Insulin secretion; Apoptosis; Adhesion; Medical Science; Medicinsk vetenskap;

   Sammanfattning : A thorough understanding of beta-cell proliferation, function, death and regeneration under normal condition as well as in the progression of diabetes is crucial to the conquest of this disease. The work presented in this thesis aimed to investigate the expression and role of a novel transcription factor, Zinc finger BED domain-containing protein 6 (ZBED6), in beta-cells. LÄS MER

3. 2. It Takes Two to Tango : Bacterial heterogeneity and host cell features govern Salmonella infection

   Författare :Viktor Ek; Mikael E. Sellin; Francisco García del Portillo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Salmonella; swimming; swim pattern; targetting; virulence; invasion; host-pathogen interactions; epithelium; epithelial cells; macrophages; monocytes; monolayer; flagella; genome; genetic; barcoding; discreet-invasion; shape; morphology; antibiotics; persistence; Mikrobiologi; Microbiology;

   Sammanfattning : Salmonella enterica serovar Typhimurium (S.Tm) causes enterocolitis with significant worldwide morbidity and mortality. The general aim of this thesis is to investigate variation in host cell invasion mechanisms used by S.Tm across different host cell contexts, as well as the influence of bacterial cell-cell heterogeneity on invasion-relevant S. LÄS MER

4. 3. Predicting oral performance of lipid-based formulations using in vitro methods

   Författare :Oliver Hedge; Christel Bergström; Frédéric Carriere; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation s ; SEDDS; artificial membrane s ; cell monolayer s ; oral drug delivery; lipolysis; permeation; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. LÄS MER

5. 4. Electrochemical monitoring of living cells

   Författare :Christer Spegel; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PC12; redox; electrochemistry; NAD P H; Single cell; Microchip; S. cerevisiae;

   Sammanfattning : This thesis presents the utilization of electroanalytical methods for analysis of dynamic cellular processes such as exocytosis, intracellular redox reactions and cell surface interactions. Microchips have been designed and manufactured with the purpose of monitoring dopamine exocytosis from single or a small ensemble of PC12 cells. LÄS MER

7. 5. Adding utility to carbon materials: introducing dopants using highly soluble metal salts and functionalizing surfaces via bromomethylation

   Författare :Samuel Joseph Fretz; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbon; Doping; Surface functionalization; Li-S batteries; Fuel cell;

   Sammanfattning : Carbon-based materials have received intense research interest over the past few decades due to their outstanding combination of properties including porosity, non-toxicity, chemical inertness, low density, and electrical conductivity, which has allowed them to find a wide array of applications including supercapacitors, batteries, CO2 capture, fuel cells and catalysis. To expand their utility, a variety of techniques have been developed to enhance their reactivity and functionality. LÄS MER