Sökning: "cell modelling"
Visar resultat 6 - 10 av 291 avhandlingar innehållade orden cell modelling.
6. Computational modelling in systems biology: from rewriting cell fates to detecting tumours
Sammanfattning : Computational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. LÄS MER
7. Of Mice and MYC : Modelling Medulloblastoma
Sammanfattning : Brain tumours are the leading cause of cancer-related paediatric deaths, with medulloblastoma (MB) being the most common malignant paediatric brain tumour. MB is stratified into four major subgroups – WNT, SHH, Group 3, and Group 4, nomenclature defined by key pathways and drivers involved within each subgroup. LÄS MER
8. From cell populations to single cells - quantitative analysis of osmotic regulation in yeast
Sammanfattning : To date, interdisciplinary research is becoming increasingly popular because it combines the achievements of diverse disciplines, having the potential of providing a completely new angle to pertinent research problems. Using increasingly sophisticated tools allowed obtaining large sets of high resolution data but also created the challenge of using this information effectively and interpreting it in a reliable way. LÄS MER
9. Three dimensional mathematical modelling of pronuclei migration for the mouse
Sammanfattning : The main question addressed in this thesis is what happens between the moment when the sperm enters the egg and the fusion of the male and the female pronuclei. Orientation of the apposing pronuclei most likely plays a decisive role in the polarity of the developing embryo. LÄS MER
10. The Effects of Genetic and Epigenetic Variation on Human Pluripotent Stem Cell Differentiation
Sammanfattning : Human pluripotent stem cells (PSCs) are widely used for studying embryonic development, disease modelling, drug discovery and cell therapy development. Using human PSCs as a model has significantly contributed to our understanding of embryonic development and elucidating novel pathological mechanisms as well as developing new drugs. LÄS MER