Sökning: "cell division orientation"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden cell division orientation.

  1. 1. Characterization of New Players in Planar Polarity Establishment in Arabidopsis

    Författare :Stefano Pietra; Markus Grebe; Niko Geldner; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SABRE; planar polarity; CLASP; cell division orientation; microtubule cytoskeleton; actin; AIP1; patterning; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : Coordinated polarity and differentiation of cells in the plane of a tissue layer are essential to the development of multicellular organisms. Arabidopsis thaliana root hairs and trichomes provide model systems to study the pathways that control planar polarity and cell fate specification in plants. LÄS MER

  3. 2. Robust and Efficient Cell-Based Models of Tissue Mechanics

    Författare :Sonja Mathias; Andreas Hellander; Ruth Baker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-based model; numerical methods; time integration; adaptivity; GPU acceleration; cell mechanics; embryonic development; cartilage formation; Beräkningsvetenskap; Scientific Computing;

    Sammanfattning : Cell-based models of tissue mechanics have become an important tool in cancer research and developmental biology. Complementary to wet-lab experiments, they allow for cost-efficient in-silico evaluation of mechanisms not easily probed in the lab. LÄS MER

  4. 3. Glypican-1: Structural and functional analysis of the N-glycosylated human protein

    Författare :Wael Awad Abdelhady; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteoglycans; glypicans; glypican-1; heparan sulphate; N-glycosylation; exostosin-proteins; X-ray crystallography; crystal dehydration; diffraction anisotropy; Small angle X-ray scattering SAXS9; protein spectroscopy;

    Sammanfattning : Glypicans are multifunctional cell surface heparan sulphate proteoglycans co-regulating numerous signalling pathways, and are thereby involved in the control of cellular division, differentiation, and morphogenesis. The heparan sulphate (HS) chains are responsible for many of those biological functions; nevertheless recent studies suggest functional roles for the glypican core proteins in mediating the signalling of various growth factors. LÄS MER

  5. 4. Chemokines and their role in dopaminergic development

    Författare :Linda C Edman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main pathological hallmark in Parkinson s disease (PD) is the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN), affecting movements such as walking, talking and writing. Today, there is no cure available for PD and existing treatments only provide symptomatic relief, but the prospect of using stem cell based cell replacement therapies for patients with PD have provided new optimism. LÄS MER

  7. 5. Models of Mechanics and Growth in Developmental Biology: A Computational Morphodinamics approach

    Författare :Behruz Bozorg; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Nyckelord :plants; morphodynamics; mechanics; anisotropy; growth; microtubules; microfibrils;

    Sammanfattning : Recent evidence has revealed the role of mechanical cues in the development of shapes in organisms. This thesis is an effort to test some of the fundamental hypotheses about the relation between mechanics and patterning in plants. To do this, we develop mechanical models designed to include specific features of plant cell walls. LÄS MER