Sökning: "cell detachment"

Visar resultat 21 - 25 av 41 avhandlingar innehållade orden cell detachment.

  1. 21. Functions of Pericytes in Ischemic Stroke

    Författare :Michaela Roth; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Stroke; Pericytes; RGS5; Blood-brain barrier; vascular remodelling; scar formation;

    Sammanfattning : Ischemic stroke remains one of the leading causes of death and disability worldwide, and its burden is predicted to further increase due to the aging population. The only available treatments, thrombolysis or thrombectomy, can only be applied within a limited time window after stroke onset, and thus are applicable only to a small proportion of stroke patients. LÄS MER

  3. 22. Pericytes in Hypoxia and Ischemic Stroke

    Författare :Andreas Enström; Translationell Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pericytes; Ischemic stroke; Hypoxia; Secretome; Transcriptome; RGS5;

    Sammanfattning : Molecular oxygen is essential for most living species. Consequently, hypoxic or ischemic conditions are major cellular stressors and prominent pathological features in ischemic stroke. Stroke is a global health problem and remains the second leading cause of death or disability worldwide. LÄS MER

  4. 23. Deciphering the Alk signaling pathway in Drosophila

    Författare :Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

    Sammanfattning : In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. LÄS MER

  5. 24. Protein tyrosine kinases and the regulation of signalling and adhesion in drosophila melanogaster

    Författare :Caroline Grabbe; Ruth Palmer; Tapio Heino; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Signalling; Adhesion; Protein Tyrosine Kinase; Development; Endocytosis; Molecular biology; Molekylärbiologi;

    Sammanfattning : In order to build a multi-cellular organism and to regulate cellular functions, cells need to communicate with each other, as well as tightly regulate their behaviour in response to environmental changes. For these purposes all eukaryotic cells express a large number of membrane spanning receptors that either themselves contain catalytic activity or via cytoplasmic effector enzymes, function to transmit “signals” from the cell exterior to induce appropriate responses within the cell. LÄS MER

  7. 25. X-LINKED RETINOSCHISIS ELECTROPHYSIOLOGY, MOLECULAR GENETICS AND TREATMENT

    Författare :Sten Kjellström; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse model; retinal degeneration; X-linked retinoschisis; XLRS; gene therapy; electroretinography;

    Sammanfattning : X-linked retinoschisis (XLRS) is a congenital progressive inherited retinal disease that affects the entire retina and is one of the more common causes of vision loss from retinal degeneration affecting young men,. The progression is variable but seems to be relatively stationary in the ages 6 to 25 years. LÄS MER