Sökning: "cell detachment"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden cell detachment.

  1. 1. Cellular interactions of HAMLET and their role in cell death

    Detta är en avhandling från Department of Microbiology, Immunology and Glycobiology, Lund University

    Författare :Maria Trulsson; Lund University.; Lunds universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HAMLET; alpha-lactalbumin; cancer; cell death; ion channels; p38; cell detachment; alpha-actinin; endocytosis; macropinocytosis; c-Myc; glycolysis;

    Sammanfattning : HAMLET is a protein-lipid complex that selectively kills tumor cells. In this thesis, we identified new mechanisms, whereby HAMLET initiates and executes tumor cell death. HAMLET targets several cellular compartments ranging from the plasma membrane to the nucleus. LÄS MER

  2. 2. Therapeutic opportunities of alpha-1-microglobulin A study in placenta, blood, skin and eye

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Martin Cederlund; Lund University.; Lunds universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reactive oxygen species; hemoglobin; myeloperoxidase; oxidative stress; α1-microglobulin;

    Sammanfattning : This thesis describes functional studies of the human protein alpha-1-microglobulin (A1M), with the aim of exploring its usefulness as a therapeutic agent in diseases where oxidative stress is a prominent feature. A1M is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding antioxidative functions. LÄS MER

  3. 3. Plasminogen in periodontitis and wound repair

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Rima Sulniute; Umeå universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The plasminogen activator (PA) system plays a critical role in many physiological and pathological processes, such as fibrinolysis, extracellular matrix (ECM) degradation, wound healing, inflammation, and cancer. The key component of the PA system is plasmin, a broad-spectrum serine protease that is derived from its inactive form, plasminogen. LÄS MER

  4. 4. Mechanisms of HAMLET-induced cancer cell death

    Detta är en avhandling från Division of Microbiology, Immunology and Glycobiology - MIG

    Författare :Sonja Aits; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-actinin; prohibitin; alpha-lactalbumin; HAMLET; cancer; cell death; autophagy; focal adhesions; c-Myc; hexokinase; glycolysis;

    Sammanfattning : HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. LÄS MER

  5. 5. Leishmania donovani Lipophosphoglycan Modulation of Macrophage and Dendritic Cell Function

    Detta är en avhandling från Institutionen för molekylär och klinisk medicin

    Författare :Katarina Tejle; Linköpings universitet.; Linköpings universitet.; [2006]
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Lipophosphoglycan; Leishmania donovani; macrophage; actin; phagocytosis; PKC alpha; dendritic cell; VETERINARY MEDICINE Microbiology and immunology; VETERINÄRMEDICIN Mikrobiologi och immunologi;

    Sammanfattning : Leishmania donovani is a blood-borne tropicial parasite, which infects humans through bites by Phlebotomus sandflies. The parasite survives and multiplies inside macrophages in inner organs, and causes the deadly disease visceral leishmaniasis (Kala-Azar). LÄS MER