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1. 1. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

   Författare :Azra Alajbegovic; Molekylär kärlfysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

   Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER

3. 2. Smac and Smac mimetics in breast cancer cell death

   Författare :Christian Holmgren; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell death; breast cancer; apoptosis; Smac mimetics; Smac; protein kinase C; TRAIL; IAP; TNFα;

   Sammanfattning : .... LÄS MER

4. 3. Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP)

   Författare :Ella Karlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; alpha cell; amylin; beta cell; chromogranin; growth; IAPP; insulin; islet amyloid polypeptide; leptin; NOD mice; pancreastatin; pancreatic islet; proliferation; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986. The aim of the present work was to determine the role of the beta cell hormone, IAPP, in normal pancreatic islet physiology and during early disturbances of islet function. LÄS MER

5. 4. Cellular targets of HAMLET, their role in tumor cell death and therapeutic potential

   Författare :Aftab Nadeem; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; colon cancer; bladder cancer; cell death; HAMLET; alpha-lactalbumin; oleate; membrane lipids; nucleotide-binding protein; Ras GTPases; alpha-helical peptides;

   Sammanfattning : Protein-lipid complexes have broad and specific effects against cancers of different origins. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded α-lactalbumin and oleic acid that kills a wide range of tumor cells but leaves healthy differentiated cells unaffected. LÄS MER

7. 5. Sugar-modulated gene expression and cell division in cell culture and seedlings of A. thaliana

   Författare :Sabine Kunz; Leszek A. Kleczkowski; Alison Smith; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Arabidopsis thaliana; carbohydrates; cell culture; cell division; gene expression; homeostasis; live cell imaging; sugar-signals; sugar-analogues; Physiological Botany; fysiologisk botanik;

   Sammanfattning : Throughout their life cycle, plants adjust growth in response to their developmental and environmental situation within the limits of their energetic capacities. This capacity is defined by the local sugar availability, which is constantly modulated through synthesis, transport and consumption of sugar. LÄS MER