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Visar resultat 1 - 5 av 109 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Extracellular Matrix Based Materials for Tissue Engineering

   Författare :Cecilia Aulin; Jöns Hilborn; Tim Bowden; Laura Creemers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Extracellular matrix; collagen synthesis; bioreactor; cell culture; bone morphogenetic protein-2; noggin; hyaluronan; cartilage; Medical technology; Medicinsk teknik; Molecular biology; Molekylärbiologi; Orthopaedics; Ortopedi; Transplantation surgery; Transplantationskirurgi; Biomaterials; Biomaterial; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Cell and molecular biology; Cell- och molekylärbiologi; Polymer chemistry; Polymerkemi; Materials chemistry; Materialkemi; cellforskning; Cell Research; materialvetenskap; Materials Science; medicinsk cellbiologi; Medical Cell Biology; ortopedi; Orthopaedics;

   Sammanfattning : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. LÄS MER

3. 2. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

   Författare :Diana Ribeiro; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vitro pancreatic models; induced pluripotent stem cells; stem cell differentiation; insulin; 3D-culture; extracellular vesicles; glucose-stimulated insulin secretion; islet amyloid polypeptide; type 2 diabetes mellitus; extracellular matrix; adipose-derived stem cells; Diabetes mellitus; protein aggregation;

   Sammanfattning : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. LÄS MER

4. 3. Cell-based models for studying paediatric high-grade gliomas

   Författare :Susanna Larsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; paediatric brain tumour; glioblastoma; glioma stem cell; primary culture; xenograft tumour; zebrafish;

   Sammanfattning : Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one of the most devastating forms with very poor prognosis due to lack of efficient treatments. LÄS MER

5. 4. The Enteric Nervous System, Plasticity and Survival

   Författare :Katarina Sandgren; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; Nitric oxide synthase; Neuropeptides; Neuronal survival; Lethal spotted mice; Interstitial cells of Cajal; Hirschsprung s disease; Cell cultures; Enteric nervous system; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : The thesis deals with plasticity in terms of neurotransmitter expression and survival of neurons in the adult enteric nervous system (ENS). Several motility disorders have been suggested to originate in developmental defects, neurodegeneration, or insufficient innervation by the ENS. LÄS MER

7. 5. Design and characterization of direct electron transfer based biofuel cells including tests in cell cultures

   Författare :Peter Lamberg; Malmö högskola; []
   Nyckelord :biofuel cell; enzymatic fuel cell; direct electron transfer; cellobiose dehydrogenase; biocompatibility; enzyme kinetics; cell culture;

   Sammanfattning : Enzymatic fuel cells (EFCs) are bioelectronic devices based on redox enzymes, which convert chemical energy into electrical energy via biochemical reactions. A major difficulty to overcome is to successfully connect (using e.g., immobilization) the enzymes to the electrode surface. LÄS MER