Sökning: "cell adhesion"

Visar resultat 16 - 20 av 630 avhandlingar innehållade orden cell adhesion.

  1. 16. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

    Författare :Shahram Hedjazifar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

    Sammanfattning : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. LÄS MER

  3. 17. Thrombospondin 1, an autocrine regulator in T cell adhesion and migration

    Författare :ShuShun Li; Karl-Gösta Sundqvist; Jan Holgersson; Claes Dahlgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; T cell; adhesion; migration; thrombospondin; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Lymphocytes, the principal cells of the immune system, perform the immune function throughout the body by their unique capacity to circulate in blood stream and lymphatic vessels and migrate in lymphoid and non-lymphoid tissues. The mechanisms regulating lymphocyte adhesion and migration, interactions with cells and components within the extracellular matrix are not fully understood. LÄS MER

  4. 18. B lymphocyte adhesion and activation

    Författare :Pia Björck; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biologi; Cytologi; Cellbiologi;

    Sammanfattning : .... LÄS MER

  5. 19. Cell Contacts and Airway Epithelial Damage in Asthma

    Författare :Shahida Shahana; Godfried Roomans; Rolf Odselius; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anatomy; Desmosomes; tight junctions; major basic protein; eosinophil; cytokines; epithelial damage.; Anatomi; Anatomy; Anatomi;

    Sammanfattning : Airway epithelial damage is commonly found in asthma patients. Epithelial damage was investigated with special reference to contacts between epithelial cells.Eosinophils, common in allergic asthma, secrete cationic proteins, particularly major basic protein (MBP). LÄS MER

  7. 20. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders

    Författare :Sethu Madhava Rao Gunja; Anders Virtanen; Jonas von Hofsten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PARN; Telomere biology disorders; snoRNAs; scaRNAs; TR TERC; Zebrafish; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Molekylär genetik; Molecular Genetics; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. LÄS MER