Sökning: "cdkn2A"
Visar resultat 1 - 5 av 52 avhandlingar innehållade ordet cdkn2A.
1. Malignant melanoma-Risk factors and the CDKN2A mutation in relation to phenotypes and other cancers
Sammanfattning : Background: Cutaneous malignant melanoma (CMM) is an increasingly common cancer in fair-skinned people. The purpose of this thesis was to study high-risk patients with multiple tumours including a CMM, high-risk families with the unique Swedish germline mutation in CDKN2A(113insArg), as well as study risk factors for CMM in women. LÄS MER
2. Dissecting Phenotypic Variation in Pigmentation using Forward and Reverse Genetics
Sammanfattning : Coat color and patterning phenotypes have been extensively studied as a model for advancing our understanding of the relationship between genetic and phenotypic variation. In this thesis, genes of relevance for pigment cell biology were investigated. The dissertation is divided in two parts. LÄS MER
3. Malignant Melanoma in southern Sweden; Histopathology, Prognosis and Aetiology
Sammanfattning : The purpose was to study the prognostic and aetiologic risk factors for melanoma in correlation to histopathology. Paper 1-3: Thin tumours (... LÄS MER
4. Molecular Genetic Alterations In Endometrial And Ovarian Cancers
Sammanfattning : Endometrial cancer is the most common gynecological cancer diagnosed in western countries. Complex atypical hyperplasia (CAH) reflects a state of hyperestrinism and its role as a precursor lesion of this cancer is established. LÄS MER
5. Of Mice and MYC : Modelling Medulloblastoma
Sammanfattning : Brain tumours are the leading cause of cancer-related paediatric deaths, with medulloblastoma (MB) being the most common malignant paediatric brain tumour. MB is stratified into four major subgroups – WNT, SHH, Group 3, and Group 4, nomenclature defined by key pathways and drivers involved within each subgroup. LÄS MER