Sökning: "caveolin"

Visar resultat 6 - 10 av 38 avhandlingar innehållade ordet caveolin.

  1. 6. Studies on the assembly of cytosolic lipid droplets. Importance of Phospholipase D and ADRP in the process

    Författare :Denis Marchesan; Göteborgs universitet; []
    Nyckelord :Lipid droplets; triglycerides; caveolin; Phospholipase D PLD ; adipocyte differentiation related protein ADRP ; EGCG;

    Sammanfattning : The storage of triglycerides in cells such as adipocytes, liver or muscle cells is of great physiological importance, having implications for our most important metabolic diseases such as obesity, the metabolic syndrome and type II diabetes. A common denominator in these diseases is the insulin resistance, which is also highly related to the production of atherogenic lipoproteins and the development of atherosclerosis and consequently cardio-vascular diseases. LÄS MER

  3. 7. Adaptive mechanisms in the hypoxic tumor microenvironment. Functional role of proteoglycans and identification of potential treatment targets

    Författare :Julien Menard; Tumörmikromiljö; []
    Nyckelord :Hypoxia; Acidosis; Proteoglycans; Endocytosis; Glioblastoma; Lipid; Caveolin-1; Antibody-drug conjugate;

    Sammanfattning : Cancer cells reside in a complex microenvironment comprising stromal cells and immune cells embedded in an extracellular matrix (ECM). Early on in tumor progression, cells reach a critical volume beyond which blood supply is impaired, leading to a decrease in oxygen levels (hypoxia) and nutrient supply. LÄS MER

  4. 8. Autosomal Dominant Leukodystrophy with Autonomic Symptoms and Rippling Muscle Disease : Translational Studies of Two Neurogenetic Diseases

    Författare :Jimmy Sundblom; Anja Smits; Raili Raininko; Niklas Dahl; Klas Kullander; Åsa Fex-Svenningsen; Marianne de Visser; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inborn genetic diseases; Leukoencephalopathies; Lamin type B; Muscular disease; Caveolin 3; Neurology; Neurologi;

    Sammanfattning : There is a large variety of diseases caused by single-gene mutations. Although most of these conditions are rare, together they impose a significant burden to the population. LÄS MER

  5. 9. Hormonal regulation of phosphodiesterase 3B in adipocytes

    Författare :Rebecka Lindh; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; diabetology; Endokrinologi; Endocrinology; caveolae localization ; phosphorylation interactions ; PDE3B adipocyte adipose tissue diabetes cAMP insulin ; lipolysis caveolin-1 ; sekretion; diabetologi;

    Sammanfattning : Insulin induced activation of the cAMP degrading enzyme phosphodiesterase (PDE) 3B in adipocytes is important for insulin mediated inhibition of lipolysis. The aim of this thesis was to contribute with knowledge on the acute activation of PDE3B in response to insulin and catecholamines in adipocytes. LÄS MER

  7. 10. Subcellular localization and signalling of Brutons tyrosine kinase (Btk)

    Författare :Leonardo Vargas-Vallejo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :B-cells; Brutons tyrosine kinase; X-linked agammaglobulinemia; pleckstrin homology domain; cytoskeleton; nucleocytoplasmic shuttling; caveolin-1; ubiquitin; SUMO-1.;

    Sammanfattning : Brutons tyrosine kinase (Btk) is a non-receptor tyrosine kinase related to the Src family of kinases. Mutations in various parts of the gene have been shown to cause X-linked agammaglobulinemia (XLA), a primary immunodeficiency in humans, characterized by a defect in B-cell development. LÄS MER