Sökning: "caspases"

Visar resultat 31 - 35 av 73 avhandlingar innehållade ordet caspases.

  1. 31. The role of autophagy in cartilage physiology and metabolism : implications for growth and ageing

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Författare :Karuna Kumari Vuppalapati; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cartilage is the main constituent of the embryonic skeleton. At the ends of long bones cartilage forms a growth plate consisting of chondrocytes in distinct stages of differentiation and arranged into three zones. These chondrocytes mediate linear bone growth through synchronized proliferation, differentiation, and production of matrix. LÄS MER

  2. 32. Roles of Myc and Mad in cell cycle and apoptosis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Författare :Ami Albihn; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myc; Mad; cell cycle; apoptosis; differentiation; tumorigenesis; chemotherapy;

    Sammanfattning : The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 interaction domain (SID) to repress transcription of target genes and prevent cell growth In contrast, members of the Myc family activate target gene transcription by recruitment of histone acetyltransferases to their transcriptional activation domain (TAD), inducing proliferation and S phase entry. LÄS MER

  3. 33. Steroids and steroid-metabolizing enzymes in the nervous system Special focus on cell survival and sex hormone synthesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ida Emanuelsson; Uppsala universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Biochemistry;

    Sammanfattning : Some steroids in the brain and peripheral nervous system have been shown to have neuroprotective effects but the knowledge is limited. The present study examines the effects of steroids including oxysterols, vitamin D and vitamin D analogs on cell viability/growth and steroidogenesis in the nervous system. LÄS MER

  4. 34. Angiostatic mechanisms of endogenous angiogenesis inhibitors

    Detta är en avhandling från Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Författare :Niina Veitonmäki; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; tumor growth; angiostatin; K 1 - 5; adiponectin; hTERT; p16;

    Sammanfattning : Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor nearly 10 years ago. The structure of angiostatin consists of the first three/four kringle (K1-3/K1-4) domains of plasminogen. LÄS MER

  5. 35. Orexin Receptors in Recombinant CHO Cells Signaling to Short- and Long-Term Cell Responses

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sylwia Ammoun; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; orexins; cell signaling; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi;

    Sammanfattning : Recently discovered neuropeptides orexins (orexin-A and -B) act as endogenous ligands for G-protein-coupled receptors called OX1 and OX2 receptors. Our previous studies have established model systems for investigation of the pharmacology and signaling of these receptors in recombinant CHO cells. LÄS MER