Sökning: "caspase-9"

Visar resultat 11 - 14 av 14 avhandlingar innehållade ordet caspase-9.

  1. 11. Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy

    Författare :Magnus Lindskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis, the aberrant lipid and phospholipid metabolism of neuroblastoma was exploited for tumor monitoring and as target of experimental therapy. Neuroblastoma is the most common and deadly solid tumor of childhood. Since neuroblastoma cells are highly proliferative, aberrantly regulated metabolic pathways would be expected. LÄS MER

  3. 12. The role of apoptosis in growth plate cartilage during normal and abnormal growth

    Författare :Dionisios Chrysis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; growth plate; dexamethasone; cytokines;

    Sammanfattning : Longitudinal bone growth occurs at the growth plate where resting chondrocytes proliferate, differentiate into a hypertrophic form, and finally become terminal hypertrophic chondrocytes before giving rise to bone. Because growth occurs when proliferation exceeds cell death, alterations in cell death by apoptosis, which is essential for the maintenance of tissue homeostasis, could affect growth. LÄS MER

  4. 13. Effects of chemotherapy on bone growth and chondrocyte cell death signaling

    Författare :Farasat Zaman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glucocorticoids (GCs) are widely used in both children and adults to treat common inflammatory diseases, including asthma, rheumatoid arthritis, ulcerative colitis and Crohn’s disease. However, a multitude of undesired side effects have been reported in patients being treated with GCs, such as osteoporosis, obesity, metabolic disturbances, myopathy and decreased linear bone growth (in children). LÄS MER

  5. 14. Apoptosis induced by a human milk protein complex. Cellular and structural studies in tumour cells and bacteria

    Författare :Anders Håkansson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; nuclear uptake; caspases; mitochondria; S. pneumoniae; alpha-lactalbumin; milk; breast-feeding; Apoptosis; tumour cells; transplantation; Immunologi; serologi;

    Sammanfattning : Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. LÄS MER