Sökning: "caspase-3"
Visar resultat 16 - 20 av 131 avhandlingar innehållade ordet caspase-3.
16. Crimean-Congo hemorragic fever virus : studies on molecular pathogenesis and host-cell interactions
Sammanfattning : Crimean-Congo haemorrhagic fever (CCHF) disease in humans shows a spectrum of severity, from mild to acute. The pathogenesis of this and other viral haemorrhagic fevers (VHF) is associated with alteration of vascular barrier function and haemorrhage, but the specific underlying mechanism is unknown. LÄS MER
17. Apoptosis in chronic inflammation, with specific reference to airway disease
Sammanfattning : Mechanisms governing the normal resolution processes of inflammation in the lung are poorly understood, yet their elucidation may lead to a greater understanding of the pathogenesis of several pulmonary inflammatory disorders. The elimination of activated lymphocytes by apoptosis is one prerequisite for resolution, and knowledge concerning the role of apoptosis in chronic inflammation is still far from complete. LÄS MER
18. Regulation of neutrophil apoptosis
Sammanfattning : The human neutrophil is the most abundant granulocyte and the major type of cell involved in an acute inflammatory response. Neutrophils are armed with various systems of enzymes, that can find and kill pathogens, but unfortunately, these "weapons" cannot distinguish between the host tissues and the "invaders. LÄS MER
19. Studies on caspase signaling in microglia
Sammanfattning : The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous system and act as the first line of defense against invading pathogens and other types of brain insults. LÄS MER
20. Regulation of apoptotic processes in neurodegeneration and cancer : In vitro studies on human neuroblastoma cells
Sammanfattning : Apoptosis is a highly controlled process of cell death, which is vital for maintenance of all multicellular organisms. Aberrant regulation of apoptosis can give rise to pathological conditions such as neurodegenerative diseases and cancer. LÄS MER