Sökning: "caspase-3"
Visar resultat 11 - 15 av 131 avhandlingar innehållade ordet caspase-3.
11. Expression and regulation of Rad51 in human cells
Sammanfattning : Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or tumorigenesis. The repair of DSBs in higher eukaryotes is to a large extent accomplished by homologous recombination (HR), a process in which DNA from a complementary strand is used as a template for repair synthesis. LÄS MER
12. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease
Sammanfattning : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). LÄS MER
13. Caspase-dependent and caspase-independent neuronal injury in the developing brain
Sammanfattning : Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed at certain time points after hypoxia-ischemia. LÄS MER
14. Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia
Sammanfattning : Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia Following prolonged disruption of blood flow to the central nervous system (CNS), or energy deprivation by other means, such as hypoglycemia, some cells will inevitably degenerate. It has been, and still is, the subject of considerable debate and intense research on brain ischemia, as to the mode of cell death, i. LÄS MER
15. Studies on microglia in tumor biology and neurobiology
Sammanfattning : Microglia are innate immune cells that reside in the central nervous system (CNS). Their activities are critical for ensuring the correct microenvironment for brain development and for maintaining homeostasis in the brain after birth. LÄS MER