Sökning: "caspase-1."

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet caspase-1..

1. 1. The role of caspase-1, caspase-4, NLRP3 and IL-1RA in bladder epithelial cells infected by uropathogenic Escherichia coli

   Författare :Anna Lindblad; Isak Demirel; Manisha Yadav; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract infection; inflammasome; uropathogenic Escherichia coli; NLRP3; caspase-1; caspase-4; IL-1RA; antimicrobial peptides; estrogen;

   Sammanfattning : Urinary tract infection is one of the most common infections and is mostlycaused by uropathogenic Escherichia coli (UPEC). The inflammasomeassociatedproteins caspase-1, caspase-4 and NLRP3 are essential in the hostcell response during urinary tract infection by regulating IL-1β release. LÄS MER

3. 2. Inflammatory cell death of human macrophages induced by Aggregatibacter actinomycetemcomitans leukotoxin

   Författare :Peyman Kelk; Anders Johansson; Charels A Dinarello; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregatibacter actinomycetemcomitans; leukotoxin; IL-1β; caspase-1; inflammatory cell death; pyroptosis; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

   Sammanfattning : Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. LÄS MER

4. 3. Macrophage Activation and AP-1 in Atherosclerosis

   Författare :Maria Stollenwerk; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Proteins; enzymology; Proteiner; enzymologi; Cardiovascular system; carotid plaque; interleukin-1b; caspase-1.; very low-density lipoprotein; fatty acids; activator protein-1; inflammation; Atherosclerosis; nuclear factor-kB; macrophages; tumor necrosis factor;

   Sammanfattning : High levels of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) have been identified as independent risk factors for coronary heart disease. Hypertriglyceridemia is generally associated with an increased expression of inflammatory makers and inflammation is thought to contribute to atherosclerosis and its complications. LÄS MER

5. 4. Staphylococcus aureus bacteremia, molecular epidemiology and host immune response

   Författare :Gunlög Rasmussen; Bo Söderquist; Kristoffer Strålin; Eva Särndahl; Peter Bergman; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Staphylococcus aureus; molecular epidemiology; DNAmicroarray; bacteremia; sepsis; NLRP3; inflammasome; caspase-1; HLA-DR; HLA-DRA; CD74;

   Sammanfattning : Staphylococcus aureus is a major pathogen responsible for a considerable disease burden worldwide. It may cause a wide array of infections, from superficial skin infections to invasive bacteremia and complications such as infective endocarditis (IE) and osteomyelitis. This thesis aimed to investigate aspects of the molecular epidemiology of S. LÄS MER

7. 5. On the role of innate cell interactions in inflammation and leukemia

   Författare :Rebecca E Riise; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate immunity; neutrophils; NK cells; caspase-1; apoptosis; myeloid leukemia; ROS; immunotherapy;

   Sammanfattning : Inflammatory cells of the innate immune system launch rapid and powerful effector responses in the combat against infectious pathogens. However, these inflammatory mediators may cause excessive damage to the host and, therefore, require rigid control systems to maintain the delicate balance between prompt clearance of infections and the risk of developing immunopathology. LÄS MER