Sökning: "cartilage degradation"
Visar resultat 1 - 5 av 24 avhandlingar innehållade orden cartilage degradation.
1. Cartilage homeostasis: Modulation of cells and extracelllar matrix assembly
Sammanfattning : The cartilage extracellular matrix consists of the collagen network which enmeshes the large aggregating proteoglycan, aggrecan. Accessory molecules regulate the formation and maintenance of these structures. This thesis studies aspects of cartilage assembly during development and its degradation in disease, focusing on the collagen network. LÄS MER
2. Interactions between extracellular matrix proteins and the complement system - In the perspective of cartilage degradation in inflammatory joint diseases
Sammanfattning : Abstract: The joint diseases osteoarthritis and rheumatoid arthritis are characterized by destructive inflammatory processes that result in pathological changes of the joint tissues, including proteolytic degradation of cartilage and release of extracellular matrix proteins or fragments to the synovial fluid. The complement system, which is a part of the innate immune system, plays a central role in promoting the joint inflammation in these diseases. LÄS MER
3. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases
Sammanfattning : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. LÄS MER
4. Three-dimensional T1 quantification techniques for assessment of cartilage quality using dGEMRIC
Sammanfattning : Osteoarthritis (OA) is a common chronic disease and one of the major global causes for functional disabilities. The disease is characterized by loss and degradation of cartilage, commonly affecting the knees and hips. LÄS MER
5. Metabolism of articular cartilage proteoglycans in vitro : effects of synovial membrane products and mechanical pressure
Sammanfattning : The effect of synovial membrane products and mechanical pressure upon the metabolism of articular cartilage proteoglycans has been studied in vitro. The degradation of cartilage proteoglycans was studied in an organ culture system and measured as the release of [35S ] sulphate from prelabelled cartilage. LÄS MER