Sökning: "cardiotoxic"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet cardiotoxic.

1. 1. Structural enzymology of the biosynthesis of polyketide antibiotics

   Författare :Anna Jansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :X-ray crystallography; anthracycline; polyketide; Streptomyces; S-adenosyl-Lmethionine; methyltransferase; hydroxylase; aldol-condensation.;

   Sammanfattning : Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, which makes them useful in treatment of various cancers. They are synthesised in the polyketide biosynthetic pathway as secondary metabolites by different Streptomyces species. LÄS MER

3. 2. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

   Författare :Magdalena Cwikiel; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER

4. 3. Therapy-resistant enuresis : In search of new therapies and prognostic markers

   Författare :Elisabet Lundmark; Tryggve Nevéus; Arne Stenberg; Sievert Lindström; Uppsala universitet; []
   Nyckelord :Nocturnal enuresis; Reboxetine; Antidepressants; Desmopressin; Voiding chart; Pediatrik; Pediatrics;

   Sammanfattning : A large minority of children with enuresis do not respond to treatment with either desmopressin or the enuresis alarm. Anticholinergics have not proven as successful as expected. The fourth evidence-based treatment of enuresis, the tricyclic antidepressant imipramine, is cardiotoxic when overdosed, which has led to diminished use. LÄS MER

5. 4. Enzymatic Reduction of Ketones

   Författare :Magnus Carlquist; Teknisk mikrobiologi; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; inhibition; flavonoids; anthracyclines; human carbonyl reductase 1; kinetic resolution; Asymmetric bioreduction; bicyclic diketones; Saccharomyces cerevisiae; Escherichia coli; AKR; SDR;

   Sammanfattning : Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. LÄS MER

7. 5. Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor

   Författare :Jeanna Perman; Göteborgs universitet; []
   Nyckelord :very low density lipoprotein receptor; lipid accumulation;

   Sammanfattning : Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as well as in hearts. LÄS MER