Sökning: "carbapenemases"

Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet carbapenemases.

1. 6. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

   Författare :Marlen Adler; Linus Sandegren; Josep Casadesús; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

   Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

3. 7. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

   Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER

4. 8. Extremely drug resistant E. coli and K. pneumoniae : novel approaches against their spread and related infections

   Författare :Angela Camporeale; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Antibiotic resistance in Enterobacteriaceae is a well-established hindrance and the spread of pathogenic high-risk clones harboring extended-spectrum -lactamases (ESBLs) and carbapenemases is posing a global health challenge, due to very less treatment alternatives. Particular lineages from the major representative species E. coli and K. LÄS MER

5. 9. On the Origins of mobile Antibiotic Resistance Genes : A comparative genomics approach

   Författare :Stefan Ebmeyer; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotic resistance; comparative genomics; bacterial genomics; antibiotic resistance genes;

   Sammanfattning : Mobile antibiotic resistance genes (ARGs), transferable between bacterial cells, are major contributors to the antibiotic resistance crisis we are facing today. From which organisms pathogens acquired these genes is mostly unknown, yet knowledge about their origin is needed in order to limit the emergence and spread of novel ARGs in the future. LÄS MER

7. 10. Multidrug-resistant Enterobacterales in Oman : molecular epidemiology and therapeutic insights

   Författare :Hissa M Al-Farsi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The spread of antibiotic resistance is a concerning issue causing limited treatment options for bacterial infections, particularly with Gram-negative bacteria. Surveillance and epidemiological studies help to determine the magnitude of the problem as well as to establish early measures to slow down the spread of resistance and consequently increase antibiotic lifespan. LÄS MER