Sökning: "carbapenem"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet carbapenem.

  1. 1. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

    Författare :Marlen Adler; Linus Sandegren; Josep Casadesús; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

    Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

  3. 2. Carbapenem resistance in Pseudomonas aeruginosa

    Författare :Christian Giske; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Carbapenem (imipenem and meropenem) resistance in Pseudomonas aeruginosa is increasing, with global resistance rates approaching 20%. The most common resistance mechanisms are down-regulation of the porin OprD, and increased activity of multi-drug efflux pumps, primarily MexAB-OprM. LÄS MER

  4. 3. Synthetic studies on carbapenem antibiotics and the alkaloid (+)-nitramine

    Författare :Hua Ming He-Williams; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  5. 4. The antimicrobial role of human MAIT cells

    Författare :Caroline Boulouis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection. MAIT cells recognize riboflavin-related metabolites produced by bacteria and presented by MR1. LÄS MER

  7. 5. Studies on the molecular mechanisms of resistance to fluoroquinolones and carbapenems in selected bacterial species

    Författare :Nagwa Mustafa El Amin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The emergence of mutant bacteria with multi-resistant phenotype, no longer responsive to any of the available therapeutic agents is a growing concern. We have investigated the resistance mechanisms to two classes of antibacterials with broad spectrum of activity, carbapenems and fluoroquinolones. LÄS MER