Sökning: "capsular serotype"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden capsular serotype.

  1. 1. Molecular epidemiology of streptococcus agalactiae : mobile elements as genetic markers

    Författare :Shi-Lu Luan; Mari Norgren; Barbara Spellerberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus agalactiae; group II intron GBSi1 ; multilocus sequence typing; capsular serotype; population structure; Clinical bacteriology; Klinisk bakteriologi;

    Sammanfattning : Streptococcus agalactiae, also designated group B streptococcus (GBS), is a Gram-positive coccus, and it is an important pathogen that causes invasive disease in neonates, pregnant adults, and non-pregnant adults with predisposing conditions. The group II intron GBSi1 is one of the major mobile genetic elements identified in S. agalactiae. LÄS MER

  3. 2. Synthesis of oligosaccharides related to the capsular polysaccharide of Neisseria meningitidis serotype A

    Författare :Peter Teodorovic; Stefan Oscarson; Mikael Elofsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Sammanfattning : In order to find suitable stable vaccine candidates against Neisseria meningitidis group A, several structures related to the capsular polysaccharide have been synthesised. The first part of the thesis describes the synthesis of C-phosphonate analogues starting from glucose. LÄS MER

  4. 3. Development of strategies for construction of thioglycoside building blocks corresponding to repeating triads of Cryptococcus neoformans GXM capsular polysaccharide

    Författare :Lina Rydner; Stefan Oscarson; Olof Ramström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Crytococcus neoformans; Capsular polysaccharide; Thioglycosides; Convergent synthesis; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis focuses on the development of methods for synthesis of thioglycoside building blocks corresponding to the repeating units of the capsular polysaccharide (CPS) of Cryptococcus neoformans, an opportunistic fungal pathogen. The building blocks are suitable for construction of large synthetic oligosaccharides related to the native CPS-structures which are to be used in biological studies in order to identify protective epitopes with the aim to develop a glycoconjugate vaccine against C. LÄS MER

  5. 4. Synthesis of oligosaccharides related to the capsular polysaccharides of Streptococcus pneumoniae serotype 9 and of Cryptococcus neoformans

    Författare :Marianne Alpe; Ulf Ellervik; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : In the present investigation, synthesis of oligosaccharides corresponding to structural elements present in the capsular polysaccharides of Streptococcus pneumoniae and Cryptococcus neoformans has been achieved. The first two sections describe the synthesis of spacer-equipped oligosaccharides corresponding to structures from the CPS of Streptococcus pneumoniae serotypes 9N, 9A and 9L, the production of which involved synthetic challenges such as the construction of β-ManNAc and α-GlcA linkages. LÄS MER

  7. 5. Mechanisms for pneumococcal meningitis and a new vaccine platform to raise a serotype-independent protection in the host

    Författare :Sigrun Thorsdottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae is a highly relevant pathogenic bacterium, responsible for a large fraction of deaths and disease morbidity in the world. The pneumococcus remains the leading cause of life-threatening pneumonia, septicemia and meningitis beyond neonatal age, despite global implementation of vaccination programs. LÄS MER