Sökning: "capsid"
Visar resultat 11 - 15 av 89 avhandlingar innehållade ordet capsid.
11. Human papillomavirus in anogenital cancer, with special reference to the viral capsid
Sammanfattning : Infection with the oncogenic types of Human Papillomavirus (HPV), particularly HPV type 16, is the major cause of anogenital dysplasias, which are precursor lesions of anogenital cancers. Studies of the HPV capsid are of interest, since HPV capsids are attractive candidates for cancer-preventive vaccines, since detection of viral capsids in clinical specimens can be used to monitor viral infectivity and spread and since HPV capsid seropositivity is a useful epidemiological marker of HPV exposure. LÄS MER
12. Studies on interactions of norovirus capsid protein with fucosylated glycans and galactosylceramide as soluble and membrane bound ligands
Sammanfattning : Noroviruses (NVs) are among the most common viral pathogens which target the gastrointestinal (GI) tract and cause severe diarrhea, vomiting and episodes of abdominal cramps with fever. Millions of people around the world get infected with NVs annually, of which 200,000 cases are estimated to be fatal. LÄS MER
13. Studies on HIV-1 core assembly
Sammanfattning : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. LÄS MER
14. Development of transgenic Arabidopsis thaliana and Daucus carota plant producing the p24 capsid protein from HIV-1 subtype C for the use as an edible plant-based vaccine model
Sammanfattning : .... LÄS MER
15. The effect of alpha-HGA on HIV-1 replication
Sammanfattning : Different classes of anti HIV-1 drugs are now available for treatment of HIV-1 infection. Although improved, these drugs show adverse effects and their long-term efficiency is severely hampered by the emergence of resistant viruses. Therefore, less toxic and more effective anti HIV-1 therapeutics agents are still needed. LÄS MER