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1. CALIBRATION OF CHROMATOGRAPHY MODELS
Sammanfattning : AbstractThis thesis is devoted to calibration of mathematical chromatography models. Chromatography models include unknown parameters that must be determined before the models can be applied to optimization or scale-up of a chromatography process. LÄS MER
2. Nanosized Bilayer Disks as Model Membranes for Interaction Studies
Sammanfattning : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. LÄS MER
3. Bioanalytical separation using capillary electrophoresis : Applications with microbubbles and proteins
Sammanfattning : In this thesis the possibilities of using capillary electrophoresis as a separation technique for analysis of proteins and microbubbles is presented.A complete analytical process consists of five necessary steps of which one is the actual analysis step. For this step a suitable analytical technique is needed. LÄS MER
4. Capillary and interstitial transport of fluid and solutes across the peritoneal membrane
Sammanfattning : According to the three-pore model of peritoneal transport the major exchange pathway between the blood and the peritoneal cavity is represented by “small pores”, permeable to small solutes and water. Osmotically induced fluid flow, as during peritoneal dialysis (PD), is postulated to occur to a great extent through a water-only pathway, whereas proteins are predicted to reach the peritoneal cavity by unidirectional convection across “large pores”. LÄS MER
5. Partitioning of Drugs and Lignin Precursor Models into Artificial Membranes
Sammanfattning : The main aim of this thesis was to characterize membrane-solute interactions using artificial membranes in immobilized liposome chromatography or capillary electrophoresis. The partitioning of a solute into a cell membrane is an essential step in diffusion across the membrane. LÄS MER