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Visar resultat 1 - 5 av 808 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Prostate cancer : epidemiological studies of risk factors

   Författare :Camilla Thellenberg Karlsson; Beatrice Malmer; Henrik Grönberg; Anders Bergh; Peter Iversen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; epidemiology; SNP; BRCA2; male breast cancer; inflammation; BPH; P53; Oncology; Onkologi;

   Sammanfattning : In spite of the fact that prostate cancer is the most common male cancer in both Sweden and many other countries in the developed world, little is known of risk factors and predisposing conditions. The only well recognized risk factors are age, race and familial aggregation. LÄS MER

3. 2. Estrogen receptor alpha and beta in breast cancer - gene expression profiles and clinical implications

   Författare :Sofia Gruvberger; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; artificial neural networks; gene expression profiling; microarray; tamoxifen; adjuvant endocrine therapy; ER; estrogen receptor beta; Breast cancer; estrogen receptor alpha; Clinical biology;

   Sammanfattning : Breast cancer is the most common malignancy in women in the Western world with about 10% of women developing breast cancer during their lifetime, of which one third will eventually succumb to the metastatic form of the disease. Breast cancer arises from the epithelial cells of the breast mammary gland, but the mechanisms involved in tumor initiation, progression, and metastasis are still not fully understood. LÄS MER

4. 3. Cancer and Inflammation : Role of Macrophages and Monocytes

   Författare :Alexander Hedbrant; Jonny Wijkander; Dick Delbro; Ann Erlandsson; Anita Sjölander; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M1 macrophages; M2 macrophages; colon cancer; lung cancer; prostaglandin E2; Biomedical Sciences; Biomedicinsk vetenskap;

   Sammanfattning : Macrophages are cells of the innate immune system that can be found in large quantities in cancer tumors and affect cancer progression by regulating growth and invasiveness of cancer cells. There are two main phenotypes of macrophages denoted M1 and M2. LÄS MER

5. 4. Clinical Aspects of Hereditary Breast Cancer

   Författare :Niklas Loman; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Cytologi; onkologi; cancerology; oncology; Cytology; Age of onset; Survival analysis; Incidence; Male breast cancer; Steroid receptors; BRCA2; BRCA1; Breast cancer; hereditary;

   Sammanfattning : A positive family history of breast cancer (BC) is one of the strongest predictors of the disease. Two major BC susceptibility genes, BRCA1 and BRCA2 were identified about a decade ago. In this thesis, studies of different biological. clinical and epidemiological aspects of hereditary BC are presented. LÄS MER

7. 5. Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer

   Författare :Åsa Kronblad; Malmö Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; General pathology; breast cancer; hypoxia; cyclin D1; Cytology; oncology; estrogen receptor; pathological anatomy; Patologi allmän ; patologisk anatomi;

   Sammanfattning : Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the receptor. LÄS MER