Sökning: "cancer immunotherapy"

Visar resultat 11 - 15 av 168 avhandlingar innehållade orden cancer immunotherapy.

  1. 11. Intratumoral CD40 stimulating therapy in patients with advanced cancer

    Författare :Sandra Irenaeus; Gustav Ullenhag; Angelica S. Loskog; Poulam Patel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40; CD40L; immunotherapy; early clinical studies; advanced cancer; intratumoral administration; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

    Sammanfattning : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. LÄS MER

  3. 12. Immunosuppressive and metastasis-promoting matrisome proteins in pancreatic cancer : the role of galectin 4 and SERPINB5

    Författare :Tommy Lidström; Daniel Öhlund; Håkan Hedman; Ola Billing; Andreas Lundqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; galectin 4; immunotherapy; SERPINB5; metastasis; extracellular matrix; drug target; Oncology; onkologi; immunologi; Immunology; Medicine; medicin;

    Sammanfattning : In Sweden 1200-1300 people are diagnosed with pancreatic ductal adenocarcinoma (PDAC) every year. Late diagnosis, together with poor treatment response and resistance to checkpoint inhibitor immunotherapy, contributes to the poor prognosis of the disease. LÄS MER

  4. 13. Biomarkers in mesothelioma and non-small cell lung cancer - Investigation of cytological specimens with correlation to histology

    Författare :Mohammed S. I. Mansour; LUCC: Lunds universitets cancercentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarker; Cytology; Cytology-histology correlation CHC ; Cytopathology; Effusion cytology; Genetic alteration; Histology; Histopathology; Immunohistochemistry; Immunotherapy; Lung cancer; Lung cytology; Mesothelioma; Molecular analysis; Non-small cell lung cancer; Oncologic pathology; Therapeutic pathology;

    Sammanfattning : .... LÄS MER

  5. 14. Immunotherapy and immunosuppression in myeloid leukemia

    Författare :Alexander Hallner; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Natural killer cells; acute myeloid leukemia; histamine dihydrochloride; immunotherapy; reactive oxygen species; chronic myelomonocytic leukemia; NK cell education; NKG2A; HLA; KIR;

    Sammanfattning : Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. LÄS MER

  7. 15. Computational exploration of cancer genomes

    Författare :Joakim Karlsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer genomics; Transcriptomics; Driver genes; Copy number changes; Immunogenomics; Cancer of unknown primary; Uveal melanoma;

    Sammanfattning : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. LÄS MER