Sökning: "calicheamicin kappa1"

Hittade 1 avhandling innehållade orden calicheamicin kappa1.

1. 1. Recognition and signaling of DNA double-strand breaks in human cells

   Författare :Ismail Hassan Ismail; Göteborgs universitet; []
   Nyckelord :DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

   Sammanfattning : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. LÄS MER