Sökning: "calcineurin inhibitors"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden calcineurin inhibitors.

  1. 1. Renal function after transplantation of the liver and intestine

    Författare :Gustaf Herlenius; Göteborgs universitet.; Gothenburg University.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adult liver transplantation; pediatric liver transplantation; intestinal transplantation; multivisceral transplantation; immunosuppression; calcineurin inhibitors; glomerular filtration rate; renal function; nephrotoxicity; chronic kidney disease; renal replacement therapy; mortality;

    Sammanfattning : Background: Chronic kidney disease (CKD) after liver (LT) or intestinal (IT) transplantation may decrease patient survival. Calcineurin inhibitors (CNI) play a major role in its development. Aims: Describe long term renal function and risk factors for developing CKD in adults and children after LT and IT. LÄS MER

  2. 2. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

    Detta är en avhandling från Wallenberg Neuroscience Center, BMC, Lund University

    Författare :Oskar Hansson; Lunds universitet.; Lund University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; basal ganglia; Parkinson s disease; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Popular Abstract in Swedish Basala ganglierna ligger under hjärnbarken i hjärnan och består av grupper av nervceller som är förbundna med varandra och med hjärnbarken. Till dessa grupper av nervceller hör striatum, globus pallidus, subthalamicus-kärnan och substantia nigra. LÄS MER

  3. 3. Effects of immunosuppressive drugs on human adipose tissue metabolism

    Detta är en avhandling från Wallenberg Neuroscience Center, BMC, Lund University

    Författare :Maria J Pereira; Göteborgs universitet.; Gothenburg University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER

  4. 4. Statin-induced cellular effects mediated by the P2X7 receptor

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Oras Mistafa; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cholesterol-lowering statins have been shown to inhibit growth of different cancer cells both in vitro and in vivo. Epidemiological studies also indicate a chemopreventive effect of statins. We have investigated the effect of statins on Akt/protein kinase B signaling and their sensitizing effect of cytostatic drugs. LÄS MER

  5. 5. Regulation of mast cell survival and apoptosis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine

    Författare :Mats Karlberg; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mature mast cells reside in the tissue as heavily granulated cells possessing a regulatory function in innate and adaptive immunity against pathogens, but also detrimentally in atopic, as well as, chronic inflammation-associated diseases such as allergic reactions and autoimmunity. Upon stimulation, mast cells release a vast variety of mediators that recruit and stimulate other immune cells, induce vasodilation and angiogenesis, and process and degrade proteins. LÄS MER