Sökning: "calbindin D28k"
Hittade 5 avhandlingar innehållade orden calbindin D28k.
1. Protein Interactions: Electrostatics and Ligand Binding
Sammanfattning : This thesis deals with Ca2+ binding to proteins, electrostatic interactions in and between proteins as well as inter- and intramolecular interactions. A computer program was developed to determine Ca2+ binding constants from experimental titration data of proteins. LÄS MER
2. Exploring the interactome of EF-hand proteins
Sammanfattning : EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. LÄS MER
3. Calcium binding protein immunoreactivity in the central auditory system and correlations with the auditory periphery : the effects of noise and aging in mice
Sammanfattning : This study has examined how calcium binding protein immunoreactivity is modulated in the cochlear nucleus and the inferior colliculus after noise exposure and during aging in mice. The effect of noise exposure on calbindin-D28k (calbindin) and parvalbumin immunoreactivity in the dorsal and posteroventral cochlear nucleus (DCN and PVCN) and inferior colliculus (IC) was studied in CBA/CBA mice by using two-dimensional quantification. LÄS MER
4. Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland
Sammanfattning : The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome stressors, and generates outputs that affect the autonomic nervous system, the endocrine system and somatomotor behaviors. LÄS MER
5. Calcium-binding proteins as markers and functional determinants of neurons in pain networks
Sammanfattning : The thesis focuses on the anatomical and cellular distribution of three EF-hand calcium binding proteins, secretagogin, neuronal calcium-binding protein 1 (NECAB1) and NECAB2 in dorsal root ganglia (DRGs) and spinal cord of three species, mouse, rat and human, and their possible roles in pathophysiological pain. In Paper I and Paper IV, we report that the expression of secretagogin is limited to a small subpopulation of peptidergic neurons in mouse and human DRGs expressing calcitonin generelated peptide (CGRP). LÄS MER