Sökning: "caffeine"
Visar resultat 16 - 20 av 54 avhandlingar innehållade ordet caffeine.
16. Metabolism of melatonin : with focus on the influence of cytochrome P4501A2
Sammanfattning : Melatonin (MT) regulates circadian rhythms. It is produced by pinealocytes. Their function is regulated by light. MT enters the blood stream by passive diffusion. LÄS MER
17. Adenosine receptors in the immature brain : with special reference to their role in hypoxic ischemia
Sammanfattning : Although the newborn brain tolerates a much longer period of oxygen deprivation and ischemia than does the adult brain, perinatal hypoxic ischemia probably is an important cause of neurological dysfunction, cerebral palsy and epilepsy later in life. Hence it is important to investigate the mechanisms that modulate the extent of perinatal ischemic brain damage. LÄS MER
18. Physiological roles of A1 and A2A adenosine receptors : studies using genetically modified mice
Sammanfattning : Since adenosine receptors were identified and cloned, their roles in animals and humans have been extensively studied. Because pharmacological tools have limitations, we have used mice in which adenosine receptors have been deleted to further study their roles under physiological and pathophysiological conditions. LÄS MER
19. The role of adenosine and its receptor subtypes in nociception and neuropathic pain
Sammanfattning : As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established that adenosine and its receptor agonists produce primarily antinociceptive effect in animals and humans. LÄS MER
20. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism
Sammanfattning : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. LÄS MER