Sökning: "cAMP signaling"

Visar resultat 21 - 25 av 62 avhandlingar innehållade orden cAMP signaling.

  1. 21. Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP

    Författare :Ulrika Krus; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; pyruvate dehydrogenase kinase; beta-cells; pyruvate carboxylase; diabetology; Endokrinologi; sekretion; diabetologi; diabetes;

    Sammanfattning : Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. LÄS MER

  3. 22. L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

    Författare :Michael Feyder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements. This complication, termed L-DOPA-induced dyskinesia (LID), represents a limitation to the most efficacious treatment for PD motor symptoms. LÄS MER

  4. 23. Canonical and noncanonical transducers for calcium signaling : role of Na,K-ATPase and angiotensin receptor

    Författare :Zuzana Khorshidi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcium (Ca2+) is the most universal and versatile signal in the cell. This versatility is based on the speed, amplitude and spatio-temporal patterning of the Ca2+ events. The inositol 1,4,5-trisphosphate receptor (IP3R) is one of the main Ca2+ channels responsible for the Ca2+ release from the intracellular stores. LÄS MER

  5. 24. The impact of glucotoxicity on pancreatic β-cell function

    Författare :Sarheed Jabar Muhammed; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Sammanfattning : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. LÄS MER

  7. 25. Intracellular signaling of phosphorylated insitol compounds : a study in pancreatic beta-cells and hippocampal neurons

    Författare :Jia Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :InsP6; L-type Ca 2 channel; hippocampal neuron; Ins 1; 4; 5 P3; Ca2 ; cyt-MIPP; pancreatic beta-cell; PtdIns 3; 4; 5 P3; Ptdlns 3; 5 P2.;

    Sammanfattning : The family of phosphorylated inositol compounds consists of soluble cytosolic inositol phosphates and insoluble inositol phospholipids, localized in cellular membranes and the nuclear matrix. Although inositol phospholipids only account for 5-10% of total plasma membrane lipids, these compounds and their inositol phosphate derivatives play an important role in a broad range of cellular processes including intracellular Ca 2+ signalling, ion channel regulation, vesicle trafficking, both exo- and endocytosis, cell growth and apoptosis. LÄS MER