Sökning: "cAMP PKA system"

Visar resultat 6 - 10 av 17 avhandlingar innehållade orden cAMP PKA system.

  1. 6. Regulation of exocytosis by Ca2+ and cAMP - A study on pancreatic beta- and alpha-cells

    Författare :Xiaosong Ma; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrinology; secreting systems; type-2 diabetes; SUR1; Ca2 -channel; glucagon; exocytosis; insulin; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. LÄS MER

  3. 7. Organic dust-induced signaling in human pulmonary epithelial cells : emphasis on effects of cAMP modulation

    Författare :Karin Burvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : To study signaling transductions in innate immunity a model system was applied where A549 alveolar epithelial type II cells were used as target and organic dust collected in swine confinement buildings as stimulus. The dust represents a complex mixture of feed and faecal particles, dander from swine, bacteria (whole bacteria and cell wall components) and fungi. LÄS MER

  4. 8. Adrenergic stimulation of glucose uptake in brown adipocytes

    Författare :Ekaterina Chernogubova; Tore Bengtsson; Barbara Cannon; Samuel Cushman; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi;

    Sammanfattning : The aim of this study was to investigate adrenergically stimulated glucose uptake in brown adipose tissue (BAT) with the focus on receptor subtypes and intracellular signalling pathways. As a model system, we used primary cultured brown adipocytes. LÄS MER

  5. 9. β-adrenergic stimulation of VEGF gene expression : intracellular signalling pathways

    Författare :Magnus J. Fredriksson; Georg Breier; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; zoofysiologi; Zoological physiology;

    Sammanfattning : In the present study, the intracellular signalling pathway mediating ß-adrenergic stimulation of the expression of the vascular endothelial growth factor (VEGF) gene was investigated.VEGF is an activator of angiogenesis, the formation of new blood vessels, and is considered to be a major regulator of both physiologically and pathologically related angiogenesis, as well as being essential for development of the vascular system. LÄS MER

  7. 10. On Cholecystokinin and Phospholipase A2 in Insulin Secretion - an Experimental Study With Reference to the Development of Diabetes

    Författare :Erik Simonsson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin Resistance; Islet; Beta-cell; Insulin Secretion; Ca2 -Dependency; Intracellular Signalling; Phospholipase A2; Cholecystokinin; Non-glucose Secretagogues; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : In view of unsolved issues regarding cellular events underlying the adaptation of insulin secretion to insulin resistance, together with the observation that insulin secretion induced by the gastrointestinal hormone and neuropeptide cholecystokinin (CCK) is not solely explained by phospholipase C-protein kinase C (PLC-PKC) pathway activation, this study aimed at delineate mechanisms responsible for the hyperinsulinemia in insulin resistance, with particular attention paid to the action of glucose vs. non-glucose secretagogues, such as CCK. LÄS MER