Sökning: "c-Myc"

Visar resultat 21 - 25 av 90 avhandlingar innehållade ordet c-Myc.

  1. 21. Transcriptional regulation of ribosome biogenesis in skeletal muscle growth

    Författare :Chang Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Resistance exercise induces skeletal muscle hypertrophy via repeated exercise bouts. The increased muscle protein synthesis together with altered muscle protein degradation contribute to the adaptation of muscle mass. The number of ribosomes dictates the protein synthetic capacity of muscle. LÄS MER

  3. 22. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

    Författare :Anders Hackzell; Göteborgs universitet; []
    Nyckelord :PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

    Sammanfattning : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. LÄS MER

  4. 23. Myc oncoprotein cofactor interactions : function, regulation and targeting

    Författare :Karin Ridderstråle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The members of the Myc-family of proto-oncoproteins c-Myc, N-Myc and L-Myc are transcription factors exerting their effect via protein-protein interactions. The Myc proteins are basic-helix-loop-helix-leucine-zipper (bHLHzip) transcription factors, which after heterodimerization with their obligatory partner Max, bind to E-boxes in target gene promoters and regulate the expression of 10-15% of all genes by the recruitment of different cofactors. LÄS MER

  5. 24. Bringing order to disorder : structural and functional analysis for development of strategies to target MYC

    Författare :Inga Müller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated expression of MYC is present in a wide range of human tumors including Burkitt´s Lymphoma, neuroblastoma, medulloblastoma, colon cancer and glioblastoma. LÄS MER

  7. 25. Targeting MYC and exploring the role of mitochondrial metabolism in childhood neuroblastoma

    Författare :Hanna Zirath; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : MYCN is a member of the MYC family of proto-oncogenes, encoding transcription factors (c-MYC, MYCN and L-MYC) that play crucial roles for normal cellular functions and during development. However, the expression of MYC (here referring to c-MYC and MYCN) is found elevated in a large number of human cancers where it is implicated in most aspects of tumorigenesis and correlates to poor clinical outcome. LÄS MER