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Visar resultat 1 - 5 av 22 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Airway effects of diesel exhaust in healthy and asthmatic subjects

    Författare :Charlotta Nordenhäll; Thomas Sandström; Ellinor Ädelroth; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; air pollution; diesel exhaust; airway responsiveness; airway inflammation; lung function; asthmatics; immunohistochemistry; bronchial epithelium;

    Sammanfattning : Several epidemiological studies have revealed an association between particulate matter (PM) pollution and various health effects. Importantly, there is evidence to suggest that individuals with pre-existing respiratory disease, such as asthma, are more sensitive to elevated ground levels of particulate matter as compared to healthy subjects. LÄS MER

  3. 2. Airway responsiveness and exhaled nitric oxide : Studies in asthma and Sjögren's syndrome

    Författare :Dóra Lúðvíksdóttir; Uppsala universitet; []
    Nyckelord :Medical sciences; Airway hyperresponsiveness; nitric oxide; airway inflammation; Sjögren s syndrome; asthma; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : In this thesis, four different types of provocation agents: methacholine, adenosine, cold air and mannitol were used to study different aspects of the airway responsiveness profile in asthma and Sjögren's syndrome. Exhaled nitric oxide (NO) and markers of eosinophil activation, serum eosinophil peroxidase (S-EPO) and eosinophil cationic protein (S-ECP) were measured. LÄS MER

  4. 3. The effect of beta2-adrenoceptor agonists and steroids on induced airway inflammation and bronchial responsiveness

    Författare :Karin Strandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute exposure of healthy subjects in a swine barn induces an intense airway inflammation and increased bronchial responsiveness. Dust collected in swine houses is a potent stimulus for release of pro-inflammatory cytokines from cells in vitro. LÄS MER

  5. 4. Effects of nitrogen dioxide on airway responsiveness in allergic asthma

    Författare :Victoria Strand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :air pollution; nitrogen dioxide; asthma; allergy; airway responsiveness; pulmonary function; eosinophils; particulates; repeated exposure;

    Sammanfattning : Asthma is one of the most common chronic diseases in the industrialized world and its prevalence is increasing. Clinical symptoms of airway obstruction and bronchial hyper responsiveness can be induced by specific agents, such as allergens and non-specific stimuli, such as cold air and irritants. LÄS MER

  7. 5. Optimizing and evaluation of a methacholine provocation test : with application in occupational research

    Författare :Britt-Marie Sundblad; Bengt-Eric Skoogh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Airway responsiveness; methacholine provocation; nitric oxide; eucapnic hyperventilation; organic dust; Fysiologi; Physiology; Fysiologi; Physiology; fysiologi;

    Sammanfattning : We have developed a methacholine provocation method, which detects bronchial responsiveness in more than 80% of healthy subjects. The method enables us to detect differences in bronchial responsiveness within the normal range. With this method FEV1 and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness. LÄS MER