Sökning: "breast cancers"

Visar resultat 1 - 5 av 204 avhandlingar innehållade orden breast cancers.

1. 1. Small breast cancers : Diagnosis, prognostic factors and clinical outcome in a screening population

   Författare :Lars-Gunnar Arnesson; Karl von Smitten; Linköpings universitet; []
   Nyckelord :Breast neoplasm; diagnostic; treatment; pathology; MEDICINE; MEDICIN;

   Sammanfattning : Breast cancer ≤ 10 mm together with ductal in situ cancer of the breast (DCIS) today constitute more than 40% of screening detected breast malignancies. Prognostic factors, diagnosis and clinical outcome for invasive breast cancers ≤ 10 mm and local recurrence in DCIS were evaluated. LÄS MER

3. 2. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

   Författare :Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
   Nyckelord :breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

   Sammanfattning : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). LÄS MER

4. 3. Breast tomosynthesis – new perspectives on breast cancer screening

   Författare :Kristina Lång; Malmö Diagnostisk radiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Breast tomosynthesis; Mammography; Breast cancer screening; Cancer detection rate; Recall rate; False positive rate; Image perception; Reading time; Lesion visualisation; Detection error;

   Sammanfattning : Abstract: Mammography is currently the established method in breast cancer screening, although the sensitivity is known be affected by overlapping tissue concealing tumours. Breast tomosynthesis takes advantage of multiple exposures at different angles reducing the negative effect of obscuring tissue. LÄS MER

5. 4. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

   Författare :Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER

7. 5. Obesity, Adipocytes and Breast Cancer – Insights from Translational Studies

   Författare :Malin Bergqvist; Bröstcancer - prevention & intervention; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Breast cancer risk; Breast cancer prognosis; Obesity; Adipocyte; Adipokines; CAP; Neutrophil to lymphocyte ratio;

   Sammanfattning : Background: Being overweight is becoming the new normal, and more than half of the adult Swedish population is overweight which poses a risk to public health. Overweight and obese women have both an increased risk and a worse prognosis for breast cancer, compared with women of normal weight. LÄS MER