Sökning: "breast cancer stem cells"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden breast cancer stem cells.

1. 1. Stem and progenitor cells in brain ad breast malignancies

   Författare :Gabriella Honeth; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural progenitor cells; glioma; migration; chemokines; cancer stem cells; breast cancer; CD44; CD24;

   Sammanfattning : Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. LÄS MER

3. 2. Patient-derived scaffolds as a 3D model for breast cancer

   Författare :Anna Gustafsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; patient-derived scaffolds; cancer microenvironment; 3D model; cancer stem cells; drug testing;

   Sammanfattning : Breast cancer is the most common cancer form in women worldwide. Many patients will have recurrent disease and more efficient targeted therapies are needed. The tumor microenvironment is a heterogenous complex mix of cells and components influencing critical cancer processes including progression, signaling and invasion. LÄS MER

4. 3. Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA

   Författare :Eleonor Olsson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer stem cells; RNA splicing; breast cancer; mutations; circulating tumor DNA; early detection of recurrent breast cancer; sequencing;

   Sammanfattning : Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. LÄS MER

5. 4. The breast cancer microenvironment and cancer cell secretion - specific effects on cancer progression and subtypes of cancer cells

   Författare :Emma Persson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; cancer microenvironment; secretion; hypoxia;

   Sammanfattning : Breast cancer is the cancer form responsible for the most cancer-related deaths among women worldwide, and novel targeted therapies are highly needed. The tumor microenvironment consists of several components, including different cell types, extracellular matrix, oxygen and nutrient gradients and soluble factors that plays a key role in cancer progression. LÄS MER

7. 5. The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome

   Författare :Karoline Berger; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; biomarker; cancer stem cells; microenvironment; progranulin; sortilin; interleukin-6; targeted therapy; prognostic;

   Sammanfattning : Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting treatment-resistant cancer stem cells. LÄS MER