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Visar resultat 1 - 5 av 168 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Clinical Aspects of Hereditary Breast Cancer

   Författare :Niklas Loman; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Cytologi; onkologi; cancerology; oncology; Cytology; Age of onset; Survival analysis; Incidence; Male breast cancer; Steroid receptors; BRCA2; BRCA1; Breast cancer; hereditary;

   Sammanfattning : A positive family history of breast cancer (BC) is one of the strongest predictors of the disease. Two major BC susceptibility genes, BRCA1 and BRCA2 were identified about a decade ago. In this thesis, studies of different biological. clinical and epidemiological aspects of hereditary BC are presented. LÄS MER

3. 2. Obesity, Adipocytes and Breast Cancer – Insights from Translational Studies

   Författare :Malin Bergqvist; Bröstcancer - prevention & intervention; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Breast cancer risk; Breast cancer prognosis; Obesity; Adipocyte; Adipokines; CAP; Neutrophil to lymphocyte ratio;

   Sammanfattning : Background: Being overweight is becoming the new normal, and more than half of the adult Swedish population is overweight which poses a risk to public health. Overweight and obese women have both an increased risk and a worse prognosis for breast cancer, compared with women of normal weight. LÄS MER

4. 3. Balancing - Cancer from a primary care perspective. Diagnosis, posttraumatic stress, and end-of-life care

   Författare :Hans Thulesius; Allmänmedicin och samhällsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medicinsk utbildning; Cytology; grounded theory; brain tumor; leukemia; child; ovarian cancer; breast cancer; prognosis; end-of-life care; screening; posttraumatic stress; diagnosis; primary care; Cancer; family practice; oncology; cancerology; Cytologi; onkologi; cancer; General practice; medical training; Allmän medicinsk utövning;

   Sammanfattning : This thesis explores cancer from a primary care perspective covering three areas: diagnosis, posttraumatic stress disorder (PTSD), and end-of-life care. We analyzed patient records of every child diagnosed with a malignancy in a defined area. During 12 years 68 children were diagnosed (incidence 14/100,000). LÄS MER

5. 4. Role of mitochondria in early molecular diagnosis and prognosis of cancer

   Författare :Yanni Li; Allmänmedicin och klinisk epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; mtDNA copy number; mitochondrial-related nuclear genes; mtDNA mutations; diagnosis; prognosis; biomarker;

   Sammanfattning : Background:Earlier clinical detection of cancer may improve survival as well as offer opportunities for less invasive treatment options. This thesis explores whether the mitochondria and its related genes in the nuclear genome can be used as novel methods for the diagnosis and prognosis of cancers. LÄS MER

7. 5. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

   Författare :Anna Isinger Ekstrand; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

   Sammanfattning : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. LÄS MER