Sökning: "brain repair"

Visar resultat 16 - 20 av 100 avhandlingar innehållade orden brain repair.

  1. 16. Trophic factors, neuroprotection and spinal cord repair

    Författare :Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Sammanfattning : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. LÄS MER

  3. 17. Development of Spatial Sequencing Methods and Applications for Brain Circuit Repair in Parkinson’s Disease

    Författare :Jana Rajova; Molekylär neuromodulering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spatial transcriptomics; Parkinson’s Disease; tissue analysis; in situ sequencing; RCA; method development; pseudotime;

    Sammanfattning : .... LÄS MER

  4. 18. Regenerating the brain : lessons from the red spotted newt

    Författare :Daniel Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Unlike mammals, adult salamanders can regenerate their brain after injury in a process fuelled by neurogenesis. The aim of this thesis is to identify the cells that give rise to new neurons after injury and examine the mechanisms controlling the initiation and termination of brain regeneration in the newt. LÄS MER

  5. 19. Regeneration in the adult brain after focal cerebral ischemia : exploration of neurogenesis and angiogenesis

    Författare :Wei Jiang; Jukka Jolkkonen; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; neurogenesis; angiogenesis; rats; mice; gliosis; BrdU; CBF; protein synthesis; ATP; penumbra; reperfusion; VEGF; 3-D confocal; photothrombosis; MCAO; Medicine; Medicin;

    Sammanfattning : Background: Ischemic stroke ranks as the third major cause of clinical mortality and the leading cause of handicap in adults. Each year, stroke occurs in about 30,000 Swedes. The severity of an acute ischemic stroke depends mainly on the degree and duration of local cerebral blood flow (lCBF) reduction. LÄS MER

  7. 20. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue

    Författare :Juan Sebastián Yakisich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA replication - Cell cycle - Brain - Gliomas - Tissue mini-unit - Protein kinases - Proteases Inhibitors - Roscovitine;

    Sammanfattning : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. LÄS MER