Sökning: "brain models"

Visar resultat 6 - 10 av 555 avhandlingar innehållade orden brain models.

  1. 6. Diffusion MRI with generalised gradient waveforms : methods, models, and neuroimaging applications

    Författare :Deneb Boito; Evren Özarslan; Magnus Herberthson; Anders Eklund; Ida Blystad; Frederik Laun; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Diffusion; Diffusion MRI; Microstructure; Brain; White matter; Microscopic anisotropy; Constrained optimisation;

    Sammanfattning : The incessant, random motion of water molecules within biological tissues reveals unique information about the tissues’ structural and functional characteristics. Diffusion magnetic resonance imaging is sensitive to this random motion, and since the mid-1990s it has been extensively employed for studying the human brain. LÄS MER

  3. 7. Modeling glioblastoma heterogeneity to decipher its biology

    Författare :Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. LÄS MER

  4. 8. Computational Models in Deep Brain Stimulation : Patient‐Specific Simulations, Tractography, and Group Analysis

    Författare :Teresa Nordin; Karin Wårdell; Simone Hemm-Ode; Johannes D. Johansson; Harith Akram; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Anisotropy; Deep brain stimulation DBS ; Finite element method FEM ; Patient‐specific simulation; Probabilistic stimulation maps PSM ; Tractography;

    Sammanfattning : Deep brain stimulation (DBS) is an established method for symptom relief in movement disorders like Parkinson’s disease, essential tremor (ET), and dystonia. The therapy is based on implanting an electrode with four contacts in the deep brain structures where it provides electrical stimulation, mainly impacting the nerve tracts. LÄS MER

  5. 9. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

    Författare :Anqi Xiong; Karin Forsberg Nilsson; Joanna Phillips; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

    Sammanfattning : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. LÄS MER

  7. 10. Immune-to-Brain Signaling in Fever : The Brain Endothelium as Interface

    Författare :Elahe Mirrasekhian; David Engblom; Anders Blomqvist; Simin Mohseni; Tomas Deierborg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Fever is a brain-regulated elevation of body temperature that occurs in response to infectious and non-infectious stimuli. During inflammatory episodes, circulating cytokines that are released by activated immune cells, trigger the induction of cyclooxygenase (COX)-2 in the ventromedial preoptic area of the hypothalamus (the thermoregulation center). LÄS MER