Sökning: "brain models"

Visar resultat 11 - 15 av 555 avhandlingar innehållade orden brain models.

  1. 11. Cerebral Mitochondrial Dysfunction and the Development of Targeted Therapeutics

    Författare :Michael Karlsson; Mitokondriell Medicin; []
    Nyckelord :mitochondria; brain; animal models; sepsis; traumatic brain injury; neuroprotection; cyclosporine;

    Sammanfattning : .... LÄS MER

  3. 12. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    Författare :Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. LÄS MER

  4. 13. Development of an Anisotropic Finite Element Head Model for Traumatic Brain Injury Prediction

    Författare :Chiara Giordano; Svein Kleiven; Songbai Ji; KTH; []
    Nyckelord :Axonal Strain; Brain Anisotropy; Traumatic Brain Injury; Finite Element Analysis; Brain Tissue; Constitutive Modeling.; Medical Technology; Medicinsk teknologi;

    Sammanfattning : Traumatic brain injury (TBI) is a worldwide health care problem with very high associatedmorbidity and mortality rates. In particular, the diagnosis of TBI is challenging: symptomsoverlap with other pathologies and the injury is typically not visible with conventionalneuroimaging techniques. LÄS MER

  5. 14. Development and Applications of in vitro Models to Study Human Brain Evolution and Disease

    Författare :Daniela Grassi; Molekylär neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural reprogramming; Neural differentiation; Brain development; Huntington s disease; Induced Neuron; Neural Progenitor Cell; Brain evolution;

    Sammanfattning : Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. LÄS MER

  7. 15. Blood Vessels, Biomarkers, and Broken Barriers: lnvestigations of the Brain Vasculature in Models of Neonatal Brain lnjuries

    Författare :E. Axel Andersson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neonatal brain injury; hypoxia ischemia; germinal matrix haemorrhage; blood brain barrier; tight‐junctions; blood vessels;

    Sammanfattning : Brain injury during the perinatal period can lead to lifelong impairment in cognitive and motor function, or an early death. Term neonatal encephalopathy and preterm germinal matrix haemorrhage are two conditions that can irreversibly injure the brain, but clinical tools for diagnosing and treating these pathologies are lacking. LÄS MER