Sökning: "brain insulin"

Visar resultat 1 - 5 av 125 avhandlingar innehållade orden brain insulin.

  1. 1. Insulin-Degrading Enzyme : A link between insulin resistance and Alzheimer's disease

    Författare :Helena Kullenberg; Marie Svedberg; Maria Kumlin; Thomas Nyström; Michael Alvarsson; Sophiahemmet Högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background: Prior research has demonstrated an elevated risk of Alzheimer's disease (AD) among individuals diagnosed with type 2 diabetes mellitus (T2DM). Insulin resistance is a potential common link between these conditions, and it is associated with AD due to the insulin-degrading enzyme (IDE), which also degrades amyloid-β (Aβ) in the brain. LÄS MER

  3. 2. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology

    Författare :Anna Edlund; Henrietta Nielsen; William Rebeck; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; insulin; metabolism; Amyloid precursor protein APP ; Fe65; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. LÄS MER

  4. 3. Regulation of insulin signaling and its developmental and functional roles on peptidergic neurons in the Drosophila central nervous system

    Författare :Jiangnan Luo; Dick Nässel; Susan Broughton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Insulin; serotonin; octopamine; insulin receptor; Dimm; neuropeptide; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : In Drosophila, eight insulin-like peptides (DILP1-8) are produced and secreted in different locations. They regulate many aspects of development and physiology, such as organism growth, metabolic homeostasis, reproduction, stress resistance and life span. LÄS MER

  5. 4. Morphological and functional effects of insulin signaling and the bHLH transcription factor Dimmed on different neuron types in Drosophila

    Författare :Yiting Liu; Dick R. Nässel; Irene Miguel-Aliaga; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; insulin signaling; Dimm; neuropeptide; insulin receptor; insulin-like peptide; drosophila; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : In Drosophila, the insulin signaling pathway is at the interface between dietary conditions and control of growth and development, reproduction, stress responses and life span. Eight insulin like peptides (Dilp1-8), an insulin tyrosine kinase receptor (dInR) and its downstream components, as well as a relaxin-like receptor type (Lgr3) form the core of this signaling. LÄS MER

  7. 5. Ischemic and Hypoglycemic Brain Damage, Involvement of the Mitochondrial Permeability Transition Pore

    Författare :Hans Friberg; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitochondrial permeability transition pore; mitochondria; apoptosis; neuronal death; brain; ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Brain damage from ischemia-reperfusion and hypoglycemia are major causes of morbidity and mortality. Therapeutic strategies include hypothermia, glutamate-receptor blockade, immunosuppression and lately treatment aiming at preserving mitochondrial integrity and function. LÄS MER