Sökning: "brain derived neurotrophic factor"

Visar resultat 16 - 20 av 99 avhandlingar innehållade orden brain derived neurotrophic factor.

1. 16. Development and preclinical assessment of novel therapies for Epilepsy. Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition

   Författare :Eliska Waloschkova; Epilepsicentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; epileptogenesis; inhibition; cell therapy; GABAergic interneurons; mesenchymal stem cells; GDNF;

   Sammanfattning : Epilepsy is one of the leading neurological disorders affecting not only patients who suffer from seizures but also people around them and society in general. The striking one third of patients not responding to pharmacological treatments implies the necessity of developing alternative options for controlling seizures in these individuals. LÄS MER

3. 17. Neurotrophic signalling by GDNF and its receptors

   Författare :Miles Trupp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Many investigators have sought a polypeptide which would alleviate the neuronal loss associated with Parkinson's disease--specifically dopaminergic neurons of the ventral mesencephalon. The survival of this population of neurons has been known for some time to be promoted by soluble factors present in the conditioned media of glial cell lines. LÄS MER

4. 18. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

   Författare :Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

   Sammanfattning : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. LÄS MER

5. 19. Neurotrophic and immune regulatory factors in neuroinflammation

   Författare :Alexander W Gielen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neurotrophins; EAE; MS; TIM; Neuroprotection;

   Sammanfattning : Inflammatory reactions in the nervous system act as a double-edged sword. On the one hand, neuroinflammation can have very devastating effects on the nervous system, leading to neurological dysfunction. LÄS MER

7. 20. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

   Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

   Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER