Sökning: "brain atrophy"

Visar resultat 1 - 5 av 87 avhandlingar innehållade orden brain atrophy.

  1. 1. Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain

    Författare :Mikael Wikgren; Karl-Fredrik Norrback; Rolf Adolfsson; Göran Roos; Thomas Karlsson; Brenda Penninx; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; aging; atrophy; brain; cognition; cortisol; depression; hippocampus; HPA axis; MRI; stress; telomere length; white matter hyper-intensities.;

    Sammanfattning : Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. LÄS MER

  3. 2. Analysis of Human Brain MRI : Contributions to Regional Volume Studies

    Författare :Richard Nordenskjöld; Joel Kullberg; Elna-Marie Larsson; Lars Johansson; Håkan Ahlström; Göran Starck; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MRI; Brain; Volume; Hemisphere; Intracranial volume; Image analysis; Computerized Image Analysis; Datoriserad bildanalys;

    Sammanfattning : Many disorders are associated with regional brain volumes. The analysis of these volumes from MR images often requires sequential processing steps such as localization and delineation. LÄS MER

  4. 3. Aerobic fitness and healthy brain aging : cognition, brain structure, and dopamine

    Författare :Lars Jonasson; Carl-Johan Boraxbekk; Katrine Riklund; Emrah Düzel; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aerobic exercise; VO2; working memory; executive function; freesurfer; striatum; dopamine; D2-receptors; [11C]raclopride;

    Sammanfattning : Background: Performing aerobic exercise and maintaining high levels of aerobic fitness may have positive effects on both brain structure and function in older adults. Despite decades of research however, there is still a rather poor understanding of the neurocognitive mechanisms explaining the positive effects of aerobic exercise on cognition. LÄS MER

  5. 4. Brain parenchymal fraction in healthy individuals and in clinical follow-up of multiple sclerosis

    Författare :Mattias Vågberg; Anders Svenningsson; Richard Birgander; Jonathan Gilthorpe; Anne-Marie Landtblom; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain parenchymal fraction; Neurofilament light; Glial fibrillary acidic protein; Brain atrophy; Multiple Sclerosis; Clinical follow-up;

    Sammanfattning : Background Multiple sclerosis (MS) is an autoimmune disease characterised by inflammatory damage to the central nervous system (CNS). Accumulated CNS injury can be quantified as brain atrophy, definable as a reduction in brain parenchymal fraction (BPF). BPF correlate with disability in MS and is used routinely as an endpoint in clinical trials. LÄS MER

  7. 5. Psychological stress in relation to dementia and brain structural changes

    Författare :Lena Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychological stress; distress; psychosocial life stressors; dementia; Alzheimer s disease; vascular dementia; white matter lesions; brain atrophy; epidemiology; longitudinal study; risk factors;

    Sammanfattning : Psychological stress has been recognized as an increasing public health problem with serious consequences in both physical and mental health. Women reported a higher prevalence of psychological stress, especially in midlife. LÄS MER